WDHD1

WD repeat and HMG-box DNA binding protein 1 is a protein in humans that is encoded by the WDHD1 gene.

WDHD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D7L
Identifiers
Aliases	WDHD1, AND-1, CHTF4, CTF4, AND1, WD repeat and HMG-box DNA binding protein 1, Ctf4
External IDs	OMIM: 608126; MGI: 2443514; HomoloGene: 56019; GeneCards: WDHD1; OMA:WDHD1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q22.2-q22.3 Start 54,938,949 bp End 55,027,105 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 C1 Start 47,478,401 bp End 47,514,314 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ventricular zone testicle ganglionic eminence secondary oocyte stromal cell of endometrium epithelium of colon mucosa of transverse colon bone marrow cells Achilles tendon Top expressed in otic placode otic vesicle primitive streak saccule tail of embryo epiblast genital tubercle ventricular zone secondary oocyte fetal liver hematopoietic progenitor cell More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding DNA binding chromatin binding RNA binding RNA polymerase binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nucleus nucleoplasm chromosome, centromeric region replication fork protection complex nuclear replication fork Biological process RNA processing regulation of chromosome organization regulation of transcription by RNA polymerase II mitotic cell cycle DNA-dependent DNA replication DNA repair cellular response to DNA damage stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11169 218973 Ensembl ENSG00000198554 ENSMUSG00000037572 UniProt O75717 P59328 RefSeq (mRNA) NM_001008396 NM_007086 NM_172598 NM_001360532 RefSeq (protein) NP_001008397 NP_009017 NP_766186 NP_001347461 Location (UCSC) Chr 14: 54.94 – 55.03 Mb Chr 14: 47.48 – 47.51 Mb PubMed search
Wikidata
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The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].