WDR57

WD repeat domain 57 (U5 snRNP specific), also known as WDR57, is a gene found in many organisms, including, but not limited to Homo sapiens, Gallus gallus, Pan troglodytes, Canus familiaris, Bos taurus, Mus musculus, and Rattus norvegicus.

SNRNP40
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JCR
Identifiers
Aliases	SNRNP40, 40K, HPRP8BP, PRP8BP, PRPF8BP, SPF38, WDR57, small nuclear ribonucleoprotein U5 subunit 40
External IDs	OMIM: 607797; MGI: 1913835; HomoloGene: 3538; GeneCards: SNRNP40; OMA:SNRNP40 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p35.2 Start 31,259,568 bp End 31,296,788 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D2.2 Start 130,253,925 bp End 130,283,819 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone mucosa of transverse colon cerebellar hemisphere C1 segment anterior pituitary right hemisphere of cerebellum ectocervix right ovary tibial nerve Top expressed in epiblast ventricular zone genital tubercle tail of embryo ganglionic eminence embryo embryo neural tube Mesencephalon bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component sno(s)RNA-containing ribonucleoprotein complex U5 snRNP catalytic step 2 spliceosome spliceosomal complex precatalytic spliceosome nucleus nucleoplasm cytosol nuclear speck U2-type catalytic step 2 spliceosome Biological process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome mRNA processing RNA processing RNA splicing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9410 66585 Ensembl ENSG00000060688 ENSMUSG00000074088 UniProt Q96DI7 Q6PE01 RefSeq (mRNA) NM_004814 NM_025645 RefSeq (protein) NP_004805 NP_079921 Location (UCSC) Chr 1: 31.26 – 31.3 Mb Chr 4: 130.25 – 130.28 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a component of the U5 small nuclear ribonucleoprotein (snRNP) particle. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs.

Interactions

WDR57 has been shown to interact with PRPF8 and EFTUD2.

Further reading

• Turner IA, Norman CM, Churcher MJ, Newman AJ (Dec 2004). "Roles of the U5 snRNP in spliceosome dynamics and catalysis". Biochemical Society Transactions. 32 (Pt 6): 928–31. doi:10.1042/BST0320928. PMID 15506927.
• Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M (Sep 1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nature Genetics. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529. S2CID 585778.
• Achsel T, Ahrens K, Brahms H, Teigelkamp S, Lührmann R (Nov 1998). "The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein". Molecular and Cellular Biology. 18 (11): 6756–66. doi:10.1128/mcb.18.11.6756. PMC 109259. PMID 9774689.
• Makarov EM, Makarova OV, Achsel T, Lührmann R (May 2000). "The human homologue of the yeast splicing factor prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions". Journal of Molecular Biology. 298 (4): 567–75. doi:10.1006/jmbi.2000.3685. PMID 10788320.
• Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (Apr 2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
• Jordanova A, Irobi J, Thomas FP, Van Dijck P, Meerschaert K, Dewil M, Dierick I, Jacobs A, De Vriendt E, Guergueltcheva V, Rao CV, Tournev I, Gondim FA, D'Hooghe M, Van Gerwen V, Callaerts P, Van Den Bosch L, Timmermans JP, Robberecht W, Gettemans J, Thevelein JM, De Jonghe P, Kremensky I, Timmerman V (Feb 2006). "Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy". Nature Genetics. 38 (2): 197–202. doi:10.1038/ng1727. PMID 16429158. S2CID 16668375.
• Liu S, Rauhut R, Vornlocher HP, Lührmann R (Jul 2006). "The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP". RNA. 12 (7): 1418–30. doi:10.1261/rna.55406. PMC 1484429. PMID 16723661.
• Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H (Nov 2006). "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation". Nature Cell Biology. 8 (11): 1277–83. doi:10.1038/ncb1490. hdl:10397/34293. PMID 17041588. S2CID 22180568.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.