Wagstaffe is a surname. Notable people with the surname include:
- Dave Wagstaffe, (1943–2013), English footballer
- Sir Joseph Wagstaffe, (1611?–1666/7), Royalist officer during the English Civil War
- Michael Wagstaffe, (born 1945), English cricketer
Fictional characters:
- Francis Wagstaffe, Created by Toby Forward and David Johnson, published in The Spiritual Quest of Francis Wagstaffe