Wake is a surname. Notable people with the surname include:
- Brian Wake (born 1982), English footballer
- Bronwyn Wake, Australian scientist
- Cameron Wake (born 1982), American football linebacker
- David B. Wake (1936–2021), American biologist and herpetologist
- Harry Wake (1901–1981), English footballer
- Hereward the Wake (c. 1035 — c. 1072), 11th-century Anglo-Saxon leader
- Sir Hereward Wake, 13th Baronet (1876-1963), British Army general
- Sir Hereward Wake, 14th Baronet (1916–2017), British Army officer and countryman
- Isaac Wake (1580–1632), English diplomat and political commentator
- Jenny Wake, New Zealand actor and theatre director
- John Wake (born 1953), English cricketer
- Jehanne Wake (born 1966), British biographer
- Joan Wake (1884–1974), British historian
- Margaret Wake, 3rd Baroness Wake of Liddell (1297–1349), wife of Edmund of Woodstock, 1st Earl of Kent
- Marvalee Wake (born 1939), American biologist
- Melissa Anne Wake, New Zealand paediatric academic
- Nancy Wake (1912–2011), New Zealand born Australian who served as a British spy during World War II
- Neil Vincent Wake (born 1948), United States federal judge
- Ric Wake, record producer
- Robert A. Wake, 1966 champion of the Scripps National Spelling Bee
- Thomas Wake, 2nd Baron Wake of Liddell (1297–1349), English baron
- Thomas Wake (disambiguation)
- William Wake (1657–1737), Archbishop of Canterbury
- Sir William Wake, 8th Baronet (1742–1785), British politician
- William Wake (cricketer) (1852–1896), English amateur first-class cricketer
- William Wake (governor), governor of Bombay