The Weizsäcker family (German: [ˈvaɪtszɛkɐ]), some with the nobiliary particle von (German pronunciation: [fɔn]), originated in the former Kingdom of Württemberg and has had prominent and influential members over several generations. Its members include a Prime Minister of the Kingdom of Württemberg, a President of Germany, a leading diplomat, a prominent environmental scientist, and the physicist after whom the Bethe–Weizsäcker formula was named.
- I. Christian Ludwig Weizsäcker (1785–1831), domestic chaplain to the Prince of Hohenlohe-Öhringen
- A. Hugo Weizsäcker (1820–1834)
- B. Karl Heinrich Weizsäcker (1822–1899), Protestant theologian and Chancellor of Tübingen University
- 1. Karl von Weizsäcker (1853–1926), 1906–1918 Ministerpräsident to King William II of Württemberg
- a. Ernst von Weizsäcker (1882–1951), diplomat who served Nazi Germany as Secretary of State for Foreign Affairs and Ambassador to the Holy See
- i. Carl Friedrich von Weizsäcker (1912–2007), physicist and philosopher
- (a). Carl Christian von Weizsäcker (born 1938), professor of political economy
- (b). Ernst Ulrich von Weizsäcker (born 1939), scientist and politician
- (1). Jakob von Weizsäcker (born 1970), economist and politician
- (c) Elisabeth Raiser (née von Weizsäcker, born 1940), historian and Protestant lay leader
- (d) Heinrich Wolfgang von Weizsäcker (born 1947), professor of mathematics
- (1). Georg von Weizsäcker (born 1973), professor of economics
- ii. Adelheid von Weizsäcker (1916–2004), m. Botho-Ernst Graf zu Eulenburg-Wicken (1903–1944)
- iii. Heinrich von Weizsäcker (1917–1939), German Army Lieutenant, killed in action (World War II)
- iiii. Richard von Weizsäcker (1920–2015), statesman and President of Germany 1984–1994, m. Marianne von Weizsäcker, née von Kretschmann (born 1932)
- (a). Robert Klaus von Weizsäcker (born 1954), professor of political economy, former president of the German Chess Federation
- (b). Andreas von Weizsäcker (1956–2008), professor of art
- (c). Beatrice von Weizsäcker (born 1958), journalist and author
- (d). Fritz von Weizsäcker (1960–2019), professor of medicine, Stabbed and killed during a class in Berlin.
- i. Carl Friedrich von Weizsäcker (1912–2007), physicist and philosopher
- b. Viktor von Weizsäcker (1886–1957), neurologist
- a. Ernst von Weizsäcker (1882–1951), diplomat who served Nazi Germany as Secretary of State for Foreign Affairs and Ambassador to the Holy See
- 1. Karl von Weizsäcker (1853–1926), 1906–1918 Ministerpräsident to King William II of Württemberg
- C. Julius Weizsäcker (1828–1889), historian
- 1. Julius Hugo Wilhelm Weizsäcker (1861–1939), lawyer
- 2. Heinrich Weizsäcker (1862–1945), professor of art history
- a. Karl Hermann Wilhelm Weizsäcker (1898–1918)