Wikipedia:Featured picture candidates/TAAR1-Dopamine neuron 2

TAAR1–Dopamine neuron pharmacodynamics diagram

Voting period is over. Please don't add any new votes. Voting period ends on 31 Aug 2014 at 20:44:59 (UTC)

Original – In this diagram, amphetamine enters the presynaptic neuron across the neuronal membrane or through the dopamine transporter (DAT).^[1] Once inside, it binds to trace amine-associated receptor 1 (TAAR1) or enters the synaptic vesicles through vesicular monoamine transporter 2 (VMAT2).^[1]^[2] When amphetamine or a trace amine (e.g., phenethylamine) binds to TAAR1, it reduces postsynaptic dopamine receptor firing rate and triggers protein kinase A (PKA) and protein kinase C (PKC) signaling, resulting in DAT phosphorylation.^[1] Phosphorylated DAT then either operates in reverse or withdraws into the presynaptic neuron and ceases transport.^[1] When amphetamine or a trace amine enters the synaptic vesicles through VMAT2, dopamine is released into the cytosol (yellow-orange area).^[2]^[3]

References

^ ^a ^b ^c ^d Miller GM (January 2011). "The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity". J. Neurochem. 116 (2): 164–176. doi:10.1111/j.1471-4159.2010.07109.x. PMC 3005101. PMID 21073468.
^ ^a ^b Eiden LE, Weihe E (January 2011). "VMAT2: a dynamic regulator of brain monoaminergic neuronal function interacting with drugs of abuse". Ann. N. Y. Acad. Sci. 1216: 86–98. doi:10.1111/j.1749-6632.2010.05906.x. PMID 21272013. VMAT2 is the CNS vesicular transporter for not only the biogenic amines DA, NE, EPI, 5-HT, and HIS, but likely also for the trace amines TYR, PEA, and thyronamine (THYR) ... [Trace aminergic] neurons in mammalian CNS would be identiﬁable as neurons expressing VMAT2 for storage, and the biosynthetic enzyme aromatic amino acid decarboxylase (AADC).
^ Offermanns S, Rosenthal W (2008). Encyclopedia of Molecular Pharmacology (2nd ed.). Berlin: Springer. pp. 1219–1222. ISBN 3540389164.

Reason: It's a helpful visual aid for explaining a technical concept – the pharmacodynamics of amphetamine and trace amines in dopamine neurons that contain trace amine-associated receptor 1.
Articles in which this image appears: Amphetamine, Adderall, Dextroamphetamine, Phenethylamine, TAAR1, Dopamine, Lisdexamfetamine, and Autoreceptor (+3 more on the German wiki )
FP category for this image: Wikipedia:Featured pictures/Diagrams, drawings, and maps/Diagrams
Creator: Seppi333

Support as nominator – Seppi333 (Insert 2¢ | Maintained) 20:44, 21 August 2014 (UTC)[reply]
@Mattximus: Hi Mattximus; I'm pinging you since I'm finally renominating this diagram.
Note: similar to my other nominated diagram for ΔFosB, this image is transcluded into articles via template:amphetamine pharmacodynamics, although it only contains a single wikitext annotation. Seppi333 (Insert 2¢ | Maintained) 20:44, 21 August 2014 (UTC)[reply]
Weak oppose Good diagram, but needs "prettying up": The outer edge of it isn't very smooth or symmetrical (and I don't see any reason not to make it fairly symmetrical), for example; "DAT internalization" is unclear as to what it refers to due to positioning, and the colours are a bit too... bold; the mustard yellow, for example. A little shading would make it look better - the solid colouurs give it a slightly MSPaint-y feel. It's a quite good diagram, it's just not quite at FP yet. Adam Cuerden ^(talk) 17:34, 22 August 2014 (UTC)[reply]

I'll see if I can tone down the boldness of the colors over the next few days. I may withdrawal this nomination since I'm not that good at manipulating the finer details in SVG diagrams though. Seppi333 (Insert 2¢ | Maintained) 04:57, 26 August 2014 (UTC)[reply]

comment is TAAR1 membrane bound? I know it can form a heterodymer with D2R which is definitely membrane bound... Mattximus (talk) 14:07, 24 August 2014 (UTC)[reply]

It's seldom, if at all, expressed along the membrane. PMID 18524885 Seppi333 (Insert 2¢ | Maintained) 04:57, 26 August 2014 (UTC)[reply]

Not Promoted --Armbrust ^{The Homunculus} 20:45, 31 August 2014 (UTC)[reply]

[Miller-1] Miller GM (January 2011). "The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity". J. Neurochem. 116 (2): 164–176. doi:10.1111/j.1471-4159.2010.07109.x. PMC 3005101. PMID 21073468.

[E_Weihe-2] Eiden LE, Weihe E (January 2011). "VMAT2: a dynamic regulator of brain monoaminergic neuronal function interacting with drugs of abuse". Ann. N. Y. Acad. Sci. 1216: 86–98. doi:10.1111/j.1749-6632.2010.05906.x. PMID 21272013. VMAT2 is the CNS vesicular transporter for not only the biogenic amines DA, NE, EPI, 5-HT, and HIS, but likely also for the trace amines TYR, PEA, and thyronamine (THYR) ... [Trace aminergic] neurons in mammalian CNS would be identiﬁable as neurons expressing VMAT2 for storage, and the biosynthetic enzyme aromatic amino acid decarboxylase (AADC).

[Offermanns-3] Offermanns S, Rosenthal W (2008). Encyclopedia of Molecular Pharmacology (2nd ed.). Berlin: Springer. pp. 1219–1222. ISBN 3540389164.

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