Wikipedia:Today's featured article/May 14, 2007

The cell nucleus is a membrane-enclosed organelle found in most eukaryotic cells. It contains most of the cell's genetic material, organized as multiple long linear DNA molecules in complex with a large variety of proteins such as histones to form chromosomes. The genes within these chromosomes make up the cell's nuclear genome. The function of the nucleus is to maintain the integrity of these genes and to control the activities of the cell by regulating gene expression. The main structural elements of the nucleus are the nuclear envelope, a double membrane that encloses the entire organelle and keeps its contents separated from the cytoplasm, and the nuclear lamina, a meshwork within the nucleus that adds mechanical support much like the cytoskeleton supports the cell as a whole. The nuclear membrane is impermeable to most molecules, and movement of molecules across the envelope is restricted to nuclear pores. Although the interior of the nucleus does not contain any membrane-delineated bodies, its contents are not uniform, and a number of subnuclear bodies exist, made up of unique proteins, RNA molecules, and DNA conglomerates. The best known of these is the nucleolus, which is mainly involved in assembly of ribosomes for translation in the cytoplasm. The nucleus was the first organelle to be discovered, and was first described by Franz Bauer in 1802. It was later described in more detail by Robert Brown in 1831. (more...)

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