Wikipedia:USEP/Courses/JHU MolBio Ogg FA13/Group 81D

Group 81D

This is a group page for the Johns Hopkins Molecular Biology course. This group will be working on the article TBD.

Use the talk page here to collaborate as a group, when learning to use and navigate Wikipedia, assessing articles, or for any other topic.

Use this page (not the talk page) for article assessments; rationale for selecting an article; etc (as specified in the milestone summary chart.

Please create a new section here for each of those assignments.

Initial Article Assessments from Rebecca Chappel

Karyogamy

The article for Karyogamy is a Stub article with High Importance. The article contains zero references and only a small amount of information in general. There is not enough information to leave the page fully knowledgeable about karyogamy. There is no discussion on the talk page.

Polysomy

The article for Polysomy is a Stub article also with High Importance. There is very little information and only one reference. There is a link to polyploidy but the information for polysomy is not enough for understanding. There are no discussions on the talk page of the current article. Information needs to be added about what consequences of polysomy are and why it occurs.

Initial Article Assessments from Jfitz1974

Histone Octamer

The Wikipedia article for Histone Octamer is currently at the Stub-Class level. It is a five sentence long article with no references or sources cited. The only discussion present on the talk page on how to improve the article is a question regarding whether the histone octamer page should be fused with the histone page.

Relevant Research

• Marino-Ramirez, Leonardo, et al. (2011) The Histone Database: an integrated respurce for histones and histone fold-containing protein.

[1]

• Eriksson, Peter, et al. (2012) Regulation of histone gene expression in budding yeast. Genetics, 191(1):7-20.

[2]

• Chantalat, L. L., Nicholson, J. M., lambert, S. J., Reid, A. J., Donovan, M. J., Reynolds, C. D., & ... Baldwin, J. P. (2003). Structure of the histone-core octamer in KCI/phosphate crystals at 2.15 Å resolution. Acta Crystallographica: Section D (Wiley-Blackwell), 59(8), 1395.

• Horn, P. J., Crowley, K. A., Carruthers, L. M., Hansen, J. C., & Peterson, C. L. (2002). The SIN domain of the histone octamer is essential for intramolecular folding of nucleosomal arrays. Nature Structural Biology, 9(3), 167.

Extrachromosomal DNA

The Wikipedia article for Extrachromosomal DNA is at the Stub-Class level. It contains no references or citations, and there are no discussions on the talk page. It gives a very brief definition of what extrachromosomal DNA is and probvides some examples of where it can found,but not much more. It talks about extrachromosomal DNA in cancerous and cultured cells, but it seems as if it was just a last minute addition- it does not flow well with the rest of the article as written.

Relevant Research

• Shibata, Yoshiyuki, et al. (2012) Extrachromsomal microDNAs and chromosomal microdeletions in normal tissues. Science, 336(6077), 82-86.

[3]

• Rush, Mark and Ravi Misra. (1985) Extrachromosomal DNA in eucaryotes. Plasmid, 14(3), 177-191.

[4]

• Goebel, W. (1970). Studies on Extrachromosomal DNA Elements. European Journal of Biochemistry, 15(2), 311-320.

Rationale For Article Selection

We chose the article “Extrachromosomal DNA” for our class project. It is a stub-class article rated with high importance on the project importance scale. The current article has no references or sources cited and has very little information provided other than a very basic definition and a few examples, leaving ample room for improvement and nearly a blank canvas with which to work. The last record of any activity on the article or talk page is from March 15, 2013 and prior to that the past activity was September 4, 2011. There is an abundance of data available describing extrachromosomal DNA and the many aspects surrounding it. There is more classic literature describing the presence of different extrachromosomal DNAs in both prokaryotes and eukaryotes as well as more recent research surrounding the biological significance of extrachromosomal DNA in disease. We feel that the page can easily become a class B or GA article with a variety of different sections from the basic description extrachromosomal DNA, to the variations between different types of organisms, to disorders and diseases caused as a result of extrachromosomal DNA, to the isolation and extraction of extrachromosomal DNA, to the uses of extrachromosomal DNA in biotechnology and medicine. The significance of DNA outside of the nucleus is important and it is a topic that we both are excited about researching and sharing information about on Wikipedia.

Unit 8 progress report

• Additional sources researched and added to list
• Created a graphic of the E. coli plasmid pBR322 using Adobe Photoshop Elements.
• Most contributions were prose

Unit 10 Progress Report

• Corrected formatting and layout issues.
• Correct References section.
• Corrected image display; created and added additional image.
• Included more prose.
• Added subsections and deleted empty sections until further research added.
• Updated internal wiki links.

Unit 12 Progress Report

• Re-arranged the layout slightly.
• Cleaned up and alphabetized the Relevant Research section.
• Added a graphic of mtDNA from Wiki Commons.
• Added a graphic of mtDNA inheritance from Wiki Commons.
• Edited irrelevant details in sections.
• Added prose.

Unit 14 Progress Report

• Updated some of the graphics.
• Added prose to the relevant research section.
• Edited for typos and overall flow.
• Cleaned-up some of the wording.
• Updated necessary references.
• Removed some tangential information.