William O. Smith may refer to:
- William Orlando Smith (1859–1932), U.S. Representative from the state of Pennsylvania
- William Osborne Smith (1833–1887), first Acting Commissioner of the North West Mounted Police
- William Owen Smith (1848–1929), lawyer in Hawaii
- Bill Smith (jazz musician) (William Overton Smith, born 1926)
See also
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This disambiguation page lists articles about people with the same name.
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