William Sims (1858–1936), was an admiral in the United States Navy.
William Sims may also refer to:
- William Dillwyn Sims (1825–1895), English industrialist and artist
- William Edward Sims (1842–1891), American politician
- William Henry Sims (1872–1955), politician in Manitoba, Canada
- William H. Sims (American politician) (1837–1920), American politician in Mississippi
- William Sims (engineer), pioneer of the Cornish engine
- William L. Sims II (1896–1977), American businessman
- William Sims (American football) (b. 1970), NFL linebacker