Wissler's syndrome is a rheumatic disease that has a similar presentation to sepsis. It is sometimes considered closely related to Still's disease.[1] It is named for Guido Fanconi and Hans Wissler [2][3] It was first described by Wissler in 1944 and Fanconi in 1946. Single observations by E. Uhse in 1943 («Febris maculosa intermittens»), Fykow in 1929 and Nowak in 1942.
| Wissler's syndrome | |
|---|---|
| Other names | Wissler's disease or Wissler-Fanconi syndrome |
| Specialty | Immunology, rheumatology  |
Signs and symptoms
editPresentation includes a symptom complex characterised by the clinical features of a high intermittent fever of septic type, constantly recurring exanthema, transient arthralgia, carditis, pleurisy, neutrophil leukocytosis, and increased erythrocyte sedimentation rate.
Causes
editThe etiology of the disease is uncertain. Wissler suggested an allergic reaction to bacteraemia as the pathogenic factor.
Diagnosis
editThis section is empty. You can help by adding to it. (September 2017) |
Epidemiology
editChildren and adolescents are most frequently affected; age in the reported cases varied from 5 to 17 years.
References
edit- ^ Fink-Puches R, Smolle J, Kerl H (February 1994). "[Wissler's allergic subsepsis]". Hautarzt (in German). 45 (2): 80–3. doi:10.1007/PL00013261. PMID 8150635. S2CID 20999040.
- ^ synd/84 at Who Named It?
- ^ H. Wissler. Über eine besondere Form sepsisähnlicher Krankheiten (Subsepsis hyperergica). Monatsschrift Kinderheilkunde, Berlin, 1943, 94: 1-15.