Woodruff House may refer to:
In the United States:
- William Woodruff House, Little Rock, Arkansas
- S.H. Woodruff Residence, Los Angeles, California, a Los Angeles Historic-Cultural Monument in Hollywood, California
- Woodruff House (Southington, Connecticut)
- Ezekiel Woodruff House, Southington, Connecticut
- Capt. Samuel Woodruff House, Southington, Connecticut
- Jotham Woodruff House, Southington, Connecticut
- Urbana Woodruff House, Southington, Connecticut
- Stanley-Woodruff-Allen House, West Hartford, Connecticut
- Ernest Woodruff House, Columbus, Georgia, listed on the National Register of Historic Places (NRHP) in Muscogee County, Georgia
- Henry Lindsay Woodruff House, Columbus, Georgia, listed on the NRHP in Muscogee County, Georgia
- Henry Lindsay Woodruff Second House, Columbus, Georgia, listed on the NRHP in Muscogee County, Georgia
- Cowles–Woodruff House, Macon, Georgia
- Woodruff House (Hillside, New Jersey)
- Woodruff House (Cornwall, New York)
- William H. Woodruff House, Green Township, Hocking County, Ohio, listed on the NRHP in Hocking County, Ohio
- Charles Woodruff House (Wyoming, Ohio)
- Asahel Hart Woodruff House, Salt Lake City, Utah, listed on the NRHP in Salt Lake City, Utah
- Woodruff Villa, Salt Lake City, Utah, listed on the NRHP in Salt Lake City, Utah
- Wilford Woodruff Farm House, Salt Lake City, Utah, listed on the NRHP in Salt Lake City, Utah, and
- Woodruff-Riter House, Salt Lake City, Utah, listed on the NRHP in Salt Lake City, Utah
- Woodruff Stake House, Woodruff, Utah
- Jacob Woodruff House, Ripon, Wisconsin