XAGE1D

G antigen family D member 2 is a protein that in humans is encoded by the XAGE1D gene.

XAGE1B
Identifiers
Aliases	XAGE1B, CT12.1, CT12.1C, CT12.1D, CT12.1E, CTP9, GAGED2, XAGE-1, XAGE1, XAGE1C, XAGE1D, X antigen family member 1E, X antigen family member 1B, XAGE1E, CT12.1b
External IDs	OMIM: 300289, 300744, 300745; HomoloGene: 135786; GeneCards: XAGE1B; OMA:XAGE1B - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xp11.22 Start 52,512,077 bp End 52,520,803 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad right testis left testis upper lobe of left lung tonsil monocyte right lung apex of heart lymph node n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 653067 n/a Ensembl ENSG00000204382 n/a UniProt Q9HD64 n/a RefSeq (mRNA) NM_001097597 NM_001097598 NM_001097602 NM_001097603 NM_001097604 NM_001097605 NM_020411 NM_133430 NM_133431 n/a RefSeq (protein) NP_001091073 NP_001091074 NP_065144 n/a Location (UCSC) Chr X: 52.51 – 52.52 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 3 transcript variants, and one of which includes 2 transcripts generated from alternate transcription initiation sites.

Further reading

• Brinkmann U, Vasmatzis G, Lee B, Pastan I (April 1999). "Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database". Cancer Research. 59 (7): 1445–8. PMID 10197611.
• Liu XF, Helman LJ, Yeung C, Bera TK, Lee B, Pastan I (September 2000). "XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma". Cancer Research. 60 (17): 4752–5. PMID 10987281.
• Zendman AJ, van Kraats AA, den Hollander AI, Weidle UH, Ruiter DJ, van Muijen GN (January 2002). "Characterization of XAGE-1b, a short major transcript of cancer/testis-associated gene XAGE-1, induced in melanoma metastasis". International Journal of Cancer. 97 (2): 195–204. doi:10.1002/ijc.1584. PMID 11774264. S2CID 36598913.
• Zendman AJ, Van Kraats AA, Weidle UH, Ruiter DJ, Van Muijen GN (May 2002). "The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma". International Journal of Cancer. 99 (3): 361–9. doi:10.1002/ijc.10371. PMID 11992404. S2CID 45958151.
• Egland KA, Kumar V, Duray P, Pastan I (May 2002). "Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers". Molecular Cancer Therapeutics. 1 (7): 441–50. PMID 12479262.
• Lim JH, Kim SP, Gabrielson E, Park YB, Park JW, Kwon TK (August 2005). "Activation of human cancer/testis antigen gene, XAGE-1, in tumor cells is correlated with CpG island hypomethylation". International Journal of Cancer. 116 (2): 200–6. doi:10.1002/ijc.21007. PMID 15800911. S2CID 25575235.
• Nakagawa K, Noguchi Y, Uenaka A, Sato S, Okumura H, Tanaka M, et al. (August 2005). "XAGE-1 expression in non-small cell lung cancer and antibody response in patients". Clinical Cancer Research. 11 (15): 5496–503. doi:10.1158/1078-0432.CCR-05-0216. PMID 16061866. S2CID 8514961.
• Sato S, Noguchi Y, Ohara N, Uenaka A, Shimono M, Nakagawa K, et al. (March 2007). "Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors". Cancer Immunity. 7: 5. PMC 2935747. PMID 17335148.