In molecular biology, the XPC binding domain is thought to play a role in DNA damage discrimination and in the enhancement of cell survival.[1] They bind specifically and directly to the xeroderma pigmentosum group C protein (XPC) to initiate nucleotide excision repair (NER).[1] Members of this entry adopt a structure consisting of four alpha helices, arranged in an array.
| XPC-binding | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 solution structure of xpc binding domain of hhr23b | |||||||||
| Identifiers | |||||||||
| Symbol | XPC-binding | ||||||||
| Pfam | PF09280 | ||||||||
| InterPro | IPR015360 | ||||||||
| SCOP2 | 1pve / SCOPe / SUPFAM | ||||||||
| |||||||||
References
edit- ^ a b Kim B, Ryu KS, Kim HJ, Cho SJ, Choi BS (2005). "Solution structure and backbone dynamics of the XPC-binding domain of the human DNA repair protein hHR23B". FEBS J. 272 (10): 2467–76. doi:10.1111/j.1742-4658.2005.04667.x. PMID 15885096. S2CID 31472776.