In molecular biology, the XPC binding domain is thought to play a role in DNA damage discrimination and in the enhancement of cell survival.[1] They bind specifically and directly to the xeroderma pigmentosum group C protein (XPC) to initiate nucleotide excision repair (NER).[1] Members of this entry adopt a structure consisting of four alpha helices, arranged in an array.

XPC-binding
solution structure of xpc binding domain of hhr23b
Identifiers
SymbolXPC-binding
PfamPF09280
InterProIPR015360
SCOP21pve / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

References

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  1. ^ a b Kim B, Ryu KS, Kim HJ, Cho SJ, Choi BS (2005). "Solution structure and backbone dynamics of the XPC-binding domain of the human DNA repair protein hHR23B". FEBS J. 272 (10): 2467–76. doi:10.1111/j.1742-4658.2005.04667.x. PMID 15885096. S2CID 31472776.
This article incorporates text from the public domain Pfam and InterPro: IPR015360