XPO6

Exportin-6 is a protein that in humans is encoded by the XPO6 gene.

XPO6
Identifiers
Aliases	XPO6, EXP6, RANBP20, exportin 6
External IDs	OMIM: 608411; MGI: 2429950; HomoloGene: 12544; GeneCards: XPO6; OMA:XPO6 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16p12.1 Start 28,097,976 bp End 28,211,965 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 F3 Start 125,700,887 bp End 125,799,673 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood granulocyte left testis right testis spleen epithelium of colon C1 segment tibial nerve upper lobe of left lung right frontal lobe Top expressed in tail of embryo genital tubercle granulocyte spermatocyte dentate gyrus of hippocampal formation granule cell ventricular zone spermatid yolk sac epiblast seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nuclear export signal receptor activity Cellular component plasma membrane nucleolus nucleus cytoplasm cytosol protein-containing complex Biological process protein transport intracellular protein transport protein export from nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23214 74204 Ensembl ENSG00000169180 ENSMUSG00000000131 UniProt Q96QU8 Q924Z6 RefSeq (mRNA) NM_001270940 NM_015171 NM_028816 NM_001311143 RefSeq (protein) NP_001257869 NP_055986 NP_001298072 NP_083092 Location (UCSC) Chr 16: 28.1 – 28.21 Mb Chr 7: 125.7 – 125.8 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Exportins, such as XPO6, recruit cargo in the nucleoplasm in the presence of Ran-GTP and form ternary export complexes. These complexes are transported through nuclear pore complexes to the cytoplasm, where GTP is hydrolyzed and the export complex is disassembled.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.