Xolani is a South African Xhosa, Zulu male given name.
Notable people with this name include:
- Xolani Dlwati, South African priest
- Xolani Mahlaba, South African cricketer
- Xolani Mdaki, South African footballer
- Xolani Mlambo, South African footballer
- Xolani Sotashe, South African politician