Xuereb is a Maltese surname.
The Xuereb surname is mentioned by Charles A. Gauci in his book The Genealogy and Heraldry of the Noble Families of Malta. He writes that the earliest references of this family are in 1517, with Tommeo Xuereb mentioned as "Nobile" or "Noble".
Notable people with the surname include:
- Aaron Xuereb (born 1979), Maltese footballer
- Alfred Xuereb (born 1958), Maltese Catholic cleric, Vatican official
- Anthony Xuereb (born 1970), Australian rugby league player
- Daniel Xuereb (born 1959), French footballer
- Janice Xuereb (born 1996), Maltese footballer
- Martin Xuereb (born 1968), Commander of the Armed Forces of Malta
- Paul Xuereb (1923–1994), Maltese politician
- Pierre-Henri Xuereb (born 1959), French violist
- Raymond Xuereb (born 1952), Maltese footballer