YM-31636

YM-31636
Names
	IUPAC name 2-(1H-imidazol-4-ylmethyl)-8H-indeno[1,2-d]thiazole
Identifiers
CAS Number	159081-22-8;
3D model (JSmol)	Interactive image;
ChemSpider	8083000;
MeSH	C419869
PubChem CID	9907348;
UNII	K9K8W6KEH2 ;
CompTox Dashboard (EPA)	DTXSID60432686 ;
	InChI InChI=1S/C14H11N3S/c1-2-4-11-9(3-1)5-12-14(11)17-13(18-12)6-10-7-15-8-16-10/h1-4,7-8H,5-6H2,(H,15,16) Key: SWXJBBYBDXFMGG-UHFFFAOYSA-N; InChI=1/C14H11N3S/c1-2-4-11-9(3-1)5-12-14(11)17-13(18-12)6-10-7-15-8-16-10/h1-4,7-8H,5-6H2,(H,15,16) Key: SWXJBBYBDXFMGG-UHFFFAOYAP;
	SMILES n2c4c1ccccc1Cc4sc2Cc3c[nH]cn3;
Properties
Chemical formula	C14H11N3S
Molar mass	253.32 g mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

YM-31636 is a potent and selective 5-HT₃ agonist.^[1] Systemic administration of YM-31636 increased the number of fecal pellets in rats, and improves colonic motility. It also increases colonic secretions, but not to the point of inducing diarrhea. In addition, it did not reduce the visceral pain threshold, or increase the intensity of visceral pain.^[2] These properties indicate that it could be a useful treatment for constipation.

References

^ Ito, H. (December 2000). "Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro". European Journal of Pharmacology. 409 (2): 195–201. doi:10.1016/S0014-2999(00)00851-7. PMID 11104834.
^ Kiso, T. (November 2001). "A novel 5-HT3 receptor agonist, YM-31636, increases gastrointestinal motility without increasing abdominal pain". European Journal of Pharmacology. 431 (1): 35–41. doi:10.1016/S0014-2999(01)01425-X. PMID 11716840.

[Ito-1] Ito, H. (December 2000). "Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro". European Journal of Pharmacology. 409 (2): 195–201. doi:10.1016/S0014-2999(00)00851-7. PMID 11104834.

[Kiso-2] Kiso, T. (November 2001). "A novel 5-HT3 receptor agonist, YM-31636, increases gastrointestinal motility without increasing abdominal pain". European Journal of Pharmacology. 431 (1): 35–41. doi:10.1016/S0014-2999(01)01425-X. PMID 11716840.

[1]

[2]