YRC could mean:
- Yorkshire Ramblers' Club (YRC), a senior mountaineering and caving club based in Yorkshire, England, UK
- York Railway (reporting mark YRC), a short line railroad operating between York and Hanover, Pennsylvania, U.S.
- YRC Freight, subsidiary of Fortune 500 American trucking company, Yellow Corporation, which was known as YRC Worldwide until 2021
- A US Navy hull classification symbol: Submarine rescue chamber (YRC)
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