Yoakum is a surname. Notable people with the surname include:
- Benjamin Franklin Yoakum (1859-1929), American railroad executive
- Charles Henderson Yoakum (1849-1909), U.S. Representative from Texas.
- Joseph Elmer Yoakum (1890-1972), self-taught artist of African-American and Native American descent
- Delmer J. Yoakum (1915-1996), American artist
- Henderson King Yoakum (1810-1856), Texas historian