Yotsuba may refer to:
- Yotsuba&!, a Japanese manga by Kiyohiko Azuma
- Yotsuba Koiwai, the title character from Yotsuba&!
- Yotsuba, a character from the manga and anime Sister Princess
- Yotsuba Nakano, a character from the manga and anime The Quintessential Quintuplets
- Yotsuba Group, the name of a group in the Japanese manga and anime Death Note
This disambiguation page lists articles associated with the title Yotsuba.
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