ZBTB21

Zinc finger and BTB domain-containing protein 21 is a protein that in humans is encoded by the ZBTB21 gene.

ZBTB21
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1WJP
Identifiers
Aliases	ZBTB21, ZNF295, zinc finger and BTB domain containing 21
External IDs	OMIM: 616485; MGI: 1927240; HomoloGene: 10799; GeneCards: ZBTB21; OMA:ZBTB21 - orthologs
Gene location (Human) Chr. Chromosome 21 (human) Band 21q22.3 Start 41,986,831 bp End 42,010,387 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 C4 Start 97,744,557 bp End 97,763,822 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tail of epididymis endothelial cell pancreatic epithelial cell corpus epididymis secondary oocyte caput epididymis Brodmann area 23 cartilage tissue mucosa of paranasal sinus Achilles tendon Top expressed in lumbar spinal ganglion zygote secondary oocyte primary oocyte tail of embryo yolk sac Rostral migratory stream Paneth cell spermatocyte otic vesicle More reference expression data BioGPS n/a
Gene ontology Molecular function methyl-CpG binding DNA binding protein binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm cytosol Biological process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 49854 114565 Ensembl ENSG00000173276 ENSMUSG00000046962 UniProt Q9ULJ3 n/a RefSeq (mRNA) NM_001098402 NM_001098403 NM_020727 NM_001320729 NM_001320731 NM_001081684 NM_001081685 NM_175428 NM_001320385 RefSeq (protein) NP_001091872 NP_001091873 NP_001307658 NP_001307660 NP_065778 n/a Location (UCSC) Chr 21: 41.99 – 42.01 Mb Chr 16: 97.74 – 97.76 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• BTB domain
• Zinc finger

Further reading

• Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Oct 1999). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
• Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (Jun 2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Molecular Vision. 8: 205–20. PMID 12107410.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Wang J, Kudoh J, Takayanagi A, Shimizu N (Feb 2005). "Novel human BTB/POZ domain-containing zinc finger protein ZNF295 is directly associated with ZFP161". Biochemical and Biophysical Research Communications. 327 (2): 615–27. doi:10.1016/j.bbrc.2004.12.048. PMID 15629158.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

• ZNF295+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.