ZC3H12A

Zinc finger CCCH-type containing 12A is a protein in humans that is encoded by the ZC3H12A gene.

ZC3H12A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3V32, 3V33, 3V34
Identifiers
Aliases	ZC3H12A, MCPIP, MCPIP1, dJ423B22.1, zinc finger CCCH-type containing 12A, Reg1, MCPIP-1
External IDs	OMIM: 610562; MGI: 2385891; HomoloGene: 11824; GeneCards: ZC3H12A; OMA:ZC3H12A - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p34.3 Start 37,474,580 bp End 37,484,377 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D2.2 Start 125,012,216 bp End 125,021,633 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gallbladder skin of abdomen gastric mucosa olfactory zone of nasal mucosa skin of leg cartilage tissue granulocyte left uterine tube upper lobe of left lung minor salivary glands Top expressed in granulocyte lip blood jejunum intestinal villus duodenum esophagus thymus muscle of thigh spleen More reference expression data BioGPS n/a
Gene ontology Molecular function miRNA binding chromatin binding metal ion binding ribonuclease activity protein binding nuclease activity endonuclease activity mRNA binding hydrolase activity ribosome binding mRNA 3'-UTR binding mRNA 3'-UTR AU-rich region binding DNA binding RNA binding endoribonuclease activity exoribonuclease activity thiol-dependent deubiquitinase RNA stem-loop binding Cellular component cytoplasm nucleoplasm cytoskeleton nucleus extrinsic component of endoplasmic reticulum membrane endoplasmic reticulum rough endoplasmic reticulum membrane rough endoplasmic reticulum P-body membrane cytoplasmic ribonucleoprotein granule protein-containing complex Biological process positive regulation of p38MAPK cascade cellular response to virus cell differentiation positive regulation of cell death positive regulation of autophagy negative regulation of interleukin-6 production positive regulation of lipid storage negative regulation of macrophage activation cellular response to tumor necrosis factor negative regulation of gene expression positive regulation of angiogenesis negative regulation of production of miRNAs involved in gene silencing by miRNA positive regulation of endothelial cell migration multicellular organism development protein deubiquitination positive regulation of gene expression positive regulation of reactive oxygen species metabolic process protein complex oligomerization angiogenesis regulation of gene expression positive regulation of protein import into nucleus negative regulation by host of viral genome replication negative regulation of tumor necrosis factor production positive regulation of miRNA catabolic process negative regulation of NF-kappaB transcription factor activity positive regulation of defense response to virus by host apoptotic process RNA phosphodiester bond hydrolysis, endonucleolytic immune system process negative regulation of muscle cell apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling transcription, DNA-templated positive regulation of fat cell differentiation positive regulation of transcription by RNA polymerase II nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay defense response to virus cellular response to glucose starvation nervous system development negative regulation of cytokine production involved in inflammatory response cellular response to sodium arsenite regulation of transcription, DNA-templated negative regulation of protein phosphorylation cellular response to ionomycin positive regulation of mRNA catabolic process cellular response to lipopolysaccharide cellular response to oxidative stress RNA phosphodiester bond hydrolysis negative regulation of nitric oxide biosynthetic process cellular response to interleukin-1 positive regulation of protein deubiquitination cellular response to chemokine inflammatory response 3'-UTR-mediated mRNA destabilization negative regulation of cardiac muscle contraction positive regulation of execution phase of apoptosis RNA phosphodiester bond hydrolysis, exonucleolytic cellular response to DNA damage stimulus immune response-activating signal transduction negative regulation of NIK/NF-kappaB signaling T cell receptor signaling pathway negative regulation of T-helper 17 cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80149 230738 Ensembl ENSG00000163874 ENSMUSG00000042677 UniProt Q5D1E8 Q5D1E7 RefSeq (mRNA) NM_025079 NM_001323550 NM_001323551 NM_153159 RefSeq (protein) NP_001310479 NP_001310480 NP_079355 NP_694799 Location (UCSC) Chr 1: 37.47 – 37.48 Mb Chr 4: 125.01 – 125.02 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

ZC3H12A (also known as MCPIP-1 and Regnase-1) is an MCP1 (CCL2; MIM 158105)-induced protein that plays an important role in cell differentiation, apoptosis and the regulation of inflammation.

Further reading

• Liang J, Wang J, Azfer A, Song W, Tromp G, Kolattukudy PE, Fu M (2008). "A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages". The Journal of Biological Chemistry. 283 (10): 6337–46. doi:10.1074/jbc.M707861200. PMID 18178554.
• Jin Z, Zheng E, Sareli C, Kolattukudy PE, Niu J (2021). "Monocyte Chemotactic Protein-Induced Protein 1 (MCPIP-1): A Key Player of Host Defense and Immune Regulation". Front. Immunol. 12: 727861. doi:10.3389/fimmu.2021.727861. PMC 8519509. PMID 34659213.