ZEB2-AS1 (ZEB2 antisense RNA 1) is a long non-coding RNA, which is overlapping and antisense to the ZEB2 gene.[3][4] It overlaps the 5′ splice site of an intron within the 5′UTR of the ZEB2 gene. This intron contains an internal ribosome entry site (IRES), which is necessary for ZEB2 expression. ZEB2-AS1 prevents the splicing of this intron, and therefore activates ZEB2 expression.[4]
| ZEB2-AS1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | ZEB2-AS1, ZEB2-AS, ZEB2AS, ZEB2NAT, ZEB2 antisense RNA 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | GeneCards: ZEB2-AS1; OMA:ZEB2-AS1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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See also
editReferences
edit- ^ a b c GRCh38: Ensembl release 89: ENSG00000238057 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Nelles L, Van de Putte T, van Grunsven L, Huylebroeck D, Verschueren K (October 2003). "Organization of the mouse Zfhx1b gene encoding the two-handed zinc finger repressor Smad-interacting protein-1". Genomics. 82 (4): 460–469. doi:10.1016/S0888-7543(03)00169-1. PMID 13679026.
- ^ a b Beltran M, Puig I, Peña C, et al. (March 2008). "A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition". Genes Dev. 22 (6): 756–769. doi:10.1101/gad.455708. PMC 2275429. PMID 18347095.
Further reading
edit- Cano A, Nieto MA (August 2008). "Non-coding RNAs take centre stage in epithelial-to-mesenchymal transition". Trends Cell Biol. 18 (8): 357–359. doi:10.1016/j.tcb.2008.05.005. PMID 18585040.
- Kumar PA, Kotlyarevska K, Dejkhmaron P, et al. (October 2010). "Growth hormone (GH)-dependent expression of a natural antisense transcript induces zinc finger E-box-binding homeobox 2 (ZEB2) in the glomerular podocyte: a novel action of gh with implications for the pathogenesis of diabetic nephropathy". J. Biol. Chem. 285 (41): 31148–31156. doi:10.1074/jbc.M110.132332. PMC 2951188. PMID 20682777.
- Mattick JS (April 2009). "The genetic signatures of noncoding RNAs". PLOS Genet. 5 (4): e1000459. doi:10.1371/journal.pgen.1000459. PMC 2667263. PMID 19390609.