ZFP91

Zinc finger protein 91 homolog is a protein that in humans is encoded by the ZFP91 gene.

ZFP91
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M9A
Identifiers
Aliases	ZFP91, DMS-8, DSM-8, PZF, ZFP-91, ZNF757, FKSG11, ZFP91 zinc finger protein, ZFP91 zinc finger protein, atypical E3 ubiquitin ligase, DSM8
External IDs	MGI: 104854; HomoloGene: 43144; GeneCards: ZFP91; OMA:ZFP91 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q12.1 Start 58,579,063 bp End 58,621,550 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19 A|19 8.73 cM Start 12,744,384 bp End 12,773,490 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle mucosa of ileum myocardium of left ventricle deltoid muscle cardiac muscle tissue of right atrium cerebellar vermis skin of arm sperm quadriceps femoris muscle cartilage tissue Top expressed in ascending aorta aortic valve Rostral migratory stream soleus muscle gastrocnemius muscle tibialis anterior muscle plantaris muscle extensor digitorum longus muscle ankle quadriceps femoris muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding nucleic acid binding ubiquitin-protein transferase activity transferase activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleolus Biological process protein K63-linked ubiquitination activation of NF-kappaB-inducing kinase activity protein ubiquitination regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80829 109910 Ensembl ENSG00000186660 ENSMUSG00000024695 UniProt Q96JP5 Q62511 RefSeq (mRNA) NM_053023 NM_001197051 NM_053009 RefSeq (protein) NP_001183980 NP_444251 NP_443735 Location (UCSC) Chr 11: 58.58 – 58.62 Mb Chr 19: 12.74 – 12.77 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2 type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. In addition to the monocistronic transcript originating from this locus, a co-transcribed variant composed of ZFP91 and CNTF sequence has been identified. The monocistronic and co-transcribed variants encode distinct isoforms. The co-transcription of ZFP91 and CNTF has also been observed in mouse.

Further reading

• Iuchi S (2001). "Three classes of C2H2 zinc finger proteins". Cell. Mol. Life Sci. 58 (4): 625–35. doi:10.1007/PL00000885. PMC 11146492. PMID 11361095. S2CID 6522993.
• Grottke C, Mantwill K, Dietel M, et al. (2000). "Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs". Int. J. Cancer. 88 (4): 535–46. doi:10.1002/1097-0215(20001115)88:4<535::AID-IJC4>3.0.CO;2-V. PMID 11058868. S2CID 24030621.
• Yu Y, Zhang C, Zhou G, et al. (2001). "Gene Expression Profiling in Human Fetal Liver and Identification of Tissue- and Developmental-Stage-Specific Genes through Compiled Expression Profiles and Efficient Cloning of Full-Length cDNAs". Genome Res. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC 311073. PMID 11483580.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Tompkins V, Hagen J, Zediak VP, Quelle DE (2006). "Identification of novel ARF binding proteins by two-hybrid screening". Cell Cycle. 5 (6): 641–6. doi:10.4161/cc.5.6.2560. PMID 16582619.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.