ZK-283197

ZK-283197
Clinical data
Other names	BAY 86-5310; SH-T04211C; ZK283197
Routes of; administration	By mouth
Drug class	Estrogen; Selective ERβ agonist
Legal status
Legal status	Investigational;
Identifiers
CAS Number	634910-57-9 ; 1644565-93-4;
PubChem CID	9839931;
PubChem SID	381127857;
UNII	G4AK6B5BV6;
Chemical and physical data
Formula	C20H25FO2
Molar mass	316.416 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@]12CC[C@]3([C@H]([C@@H]1C[C@H]([C@@H]2F)O)CCC4=C3C=CC(=C4)O)C=C;
	InChI InChI=1S/C20H25FO2/c1-3-20-9-8-19(2)16(11-17(23)18(19)21)15(20)6-4-12-10-13(22)5-7-14(12)20/h3,5,7,10,15-18,22-23H,1,4,6,8-9,11H2,2H3/t15-,16-,17+,18-,19-,20+/m0/s1; Key:LXLNOGZWGYFWQV-CFSBILQPSA-N;

ZK-283197 (also known as BAY 86-5310 or SH-T04211C) is a selective and orally active ERβ agonist which was under development by Bayer Healthcare AG for the treatment of vasomotor symptoms.^[1]^[2] It reached phase II clinical trials prior to the discontinuation of its development.^[1] Its development was terminated in 2014.^[1]

References

^ ^a ^b ^c ^d "ZK 283197". AdisInsight. Springer Nature Switzerland AG.
^ US 332204, Pietras RJ, Jung ME, "Methods of using estrogen receptor-beta ligands as radiation mitigators", published 2015-01-15

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Clinical data

Other names	BAY 86-5310; SH-T04211C; ZK283197
Routes of administration	By mouth^[1]
Drug class	Estrogen; Selective ERβ agonist
Legal status
Legal status	Investigational
Identifiers
CAS Number	634910-57-9 1644565-93-4
PubChem CID	9839931
PubChem SID	381127857
UNII	G4AK6B5BV6
Chemical and physical data
Formula	C₂₀H₂₅FO₂
Molar mass	316.416 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C[C@]12CC[C@]3([C@H]([C@@H]1C[C@H]([C@@H]2F)O)CCC4=C3C=CC(=C4)O)C=C
InChI InChI=1S/C20H25FO2/c1-3-20-9-8-19(2)16(11-17(23)18(19)21)15(20)6-4-12-10-13(22)5-7-14(12)20/h3,5,7,10,15-18,22-23H,1,4,6,8-9,11H2,2H3/t15-,16-,17+,18-,19-,20+/m0/s1 Key:LXLNOGZWGYFWQV-CFSBILQPSA-N