ZKSCAN5

Zinc finger protein with KRAB and SCAN domains 5 is a protein that in humans is encoded by the ZKSCAN5 gene. The protein contains a SCAN box and a KRAB A domain.

ZKSCAN5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EM5, 2EMM, 2EMZ, 2EN3, 2EOM, 2EON, 2EOO, 2YSO, 2YTG
Identifiers
Aliases	ZKSCAN5, ZFP95, ZNF914, ZSCAN37, ZFP-95, zinc finger with KRAB and SCAN domains 5
External IDs	OMIM: 611272; MGI: 107533; HomoloGene: 8734; GeneCards: ZKSCAN5; OMA:ZKSCAN5 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q22.1 Start 99,504,662 bp End 99,534,700 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 G2 Start 145,141,372 bp End 145,158,560 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii gonad testicle ventricular zone ganglionic eminence sperm stromal cell of endometrium muscle of thigh islet of Langerhans gastrocnemius muscle Top expressed in secondary oocyte spermatocyte zygote primary oocyte ankle joint seminiferous tubule ventricular zone genital tubercle muscle of thigh female urethra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding zinc ion binding protein binding metal ion binding nucleic acid binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component intracellular anatomical structure nucleus Biological process transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23660 22757 Ensembl ENSG00000196652 ENSMUSG00000055991 UniProt Q9Y2L8 Q9Z1D8 RefSeq (mRNA) NM_014569 NM_145102 NM_001318082 NM_001318083 NM_001318084 NM_001167944 NM_016683 NM_001359187 NM_001359188 NM_001359189 NM_001359190 NM_001359191 NM_001359192 RefSeq (protein) NP_001305011 NP_001305012 NP_001305013 NP_055384 NP_659570 NP_001161416 NP_057892 NP_001346116 NP_001346117 NP_001346118 NP_001346119 NP_001346120 NP_001346121 Location (UCSC) Chr 7: 99.5 – 99.53 Mb Chr 5: 145.14 – 145.16 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

A similar protein in mice is differentially expressed in spermatogenesis. Two alternatively spliced transcript variants differing only in the five prime untranslated region (5' UTR) have been described. Additional variants have been found, but their full-length sequences have not been determined.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Thompson EE, Kuttab-Boulos H, Yang L, et al. (2006). "Sequence diversity and haplotype structure at the human CYP3A cluster". Pharmacogenomics J. 6 (2): 105–14. doi:10.1038/sj.tpj.6500347. PMID 16314882.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.