ZNF143

Zinc finger protein 143 is a protein that in humans is encoded by the ZNF143 gene.

ZNF143
Identifiers
Aliases	ZNF143, SBF, STAF, pHZ-1, zinc finger protein 143
External IDs	OMIM: 603433; MGI: 1277969; HomoloGene: 56444; GeneCards: ZNF143; OMA:ZNF143 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.4 Start 9,460,319 bp End 9,528,524 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 E3|7 57.7 cM Start 109,660,424 bp End 109,694,601 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ventricular zone ganglionic eminence monocyte gonad testicle islet of Langerhans left testis right testis epithelium of colon Top expressed in granulocyte morula morula primary oocyte tail of embryo zygote ganglionic eminence blood genital tubercle neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleic acid binding DNA binding protein binding metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity Cellular component nucleus nucleoplasm Biological process regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase III regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated transcription by RNA polymerase III snRNA transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7702 20841 Ensembl ENSG00000166478 ENSMUSG00000061079 UniProt P52747 O70230 RefSeq (mRNA) NM_001282656 NM_001282657 NM_003442 NM_009281 NM_001374618 RefSeq (protein) NP_001269585 NP_001269586 NP_003433 NP_033307 NP_001361547 NP_001392700 NP_001392701 Location (UCSC) Chr 11: 9.46 – 9.53 Mb Chr 7: 109.66 – 109.69 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Tommerup N, Vissing H (1995). "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders". Genomics. 27 (2): 259–64. doi:10.1006/geno.1995.1040. PMID 7557990.
• Schuster C, Myslinski E, Krol A, Carbon P (1995). "Staf, a novel zinc finger protein that activates the RNA polymerase III promoter of the selenocysteine tRNA gene". EMBO J. 14 (15): 3777–87. doi:10.1002/j.1460-2075.1995.tb00047.x. PMC 394452. PMID 7641696.
• Schaub M, Myslinski E, Schuster C, et al. (1997). "Staf, a promiscuous activator for enhanced transcription by RNA polymerases II and III". EMBO J. 16 (1): 173–81. doi:10.1093/emboj/16.1.173. PMC 1169624. PMID 9009278.
• Schuster C, Krol A, Carbon P (1998). "Two distinct domains in Staf to selectively activate small nuclear RNA-type and mRNA promoters". Mol. Cell. Biol. 18 (5): 2650–8. doi:10.1128/mcb.18.5.2650. PMC 110644. PMID 9566884.
• Myslinski E, Krol A, Carbon P (1998). "ZNF76 and ZNF143 are two human homologs of the transcriptional activator Staf". J. Biol. Chem. 273 (34): 21998–2006. doi:10.1074/jbc.273.34.21998. PMID 9705341.
• Rincon JC, Engler SK, Hargrove BW, Kunkel GR (1998). "Molecular cloning of a cDNA encoding human SPH-binding factor, a conserved protein that binds to the enhancer-like region of the U6 small nuclear RNA gene promoter". Nucleic Acids Res. 26 (21): 4846–52. doi:10.1093/nar/26.21.4846. PMC 147939. PMID 9776743.
• Mach CM, Hargrove BW, Kunkel GR (2002). "The Small RNA gene activator protein, SphI postoctamer homology-binding factor/selenocysteine tRNA gene transcription activating factor, stimulates transcription of the human interferon regulatory factor-3 gene". J. Biol. Chem. 277 (7): 4853–8. doi:10.1074/jbc.M108308200. PMID 11724783.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Grossman CE, Qian Y, Banki K, Perl A (2004). "ZNF143 mediates basal and tissue-specific expression of human transaldolase". J. Biol. Chem. 279 (13): 12190–205. doi:10.1074/jbc.M307039200. PMID 14702349.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wakasugi T, Izumi H, Uchiumi T, et al. (2007). "ZNF143 interacts with p73 and is involved in cisplatin resistance through the transcriptional regulation of DNA repair genes". Oncogene. 26 (36): 5194–203. doi:10.1038/sj.onc.1210326. PMID 17297437. S2CID 21482216.
• Myslinski E, Gérard MA, Krol A, Carbon P (2007). "Transcription of the human cell cycle regulated BUB1B gene requires hStaf/ZNF143". Nucleic Acids Res. 35 (10): 3453–64. doi:10.1093/nar/gkm239. PMC 1904299. PMID 17478512.
• Gérard MA, Krol A, Carbon P (2007). "Transcription factor hStaf/ZNF143 is required for expression of the human TFAM gene". Gene. 401 (1–2): 145–53. doi:10.1016/j.gene.2007.07.011. PMID 17707600.
• Yuan CC, Zhao X, Florens L, et al. (2007). "CHD8 associates with human Staf and contributes to efficient U6 RNA polymerase III transcription". Mol. Cell. Biol. 27 (24): 8729–38. doi:10.1128/MCB.00846-07. PMC 2169411. PMID 17938208.

External links

• ZNF143+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook Znf143

This article incorporates text from the United States National Library of Medicine, which is in the public domain.