ZNF16

Zinc finger protein 16 is a protein that in humans is encoded by the ZNF16 gene.

ZNF16
Identifiers
Aliases	ZNF16, HZF1, KOX9, zinc finger protein 16
External IDs	OMIM: 601262; HomoloGene: 56008; GeneCards: ZNF16; OMA:ZNF16 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8q24.3 Start 144,930,358 bp End 144,950,888 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle oocyte ganglionic eminence gastrocnemius muscle muscle of thigh secondary oocyte ventricular zone skin of leg gingival epithelium n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleolus Biological process positive regulation of cell cycle phase transition positive regulation of kinase activity cell cycle negative regulation of apoptotic process regulation of transcription, DNA-templated positive regulation of megakaryocyte differentiation positive regulation of cell division positive regulation of erythrocyte differentiation transcription, DNA-templated positive regulation of cell population proliferation cellular response to sodium dodecyl sulfate cell division regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7564 n/a Ensembl ENSG00000170631 n/a UniProt P17020 n/a RefSeq (mRNA) NM_001029976 NM_006958 n/a RefSeq (protein) NP_001025147 NP_008889 n/a Location (UCSC) Chr 8: 144.93 – 144.95 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

The protein encoded by this gene contains a C2H2 type of zinc finger, and thus may function as a transcription factor. This gene is located in a region close to ZNF7/KOX4, a gene also encoding a zinc finger protein, on chromosome 8. Two alternatively spliced variants, encoding the same protein, have been identified.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Dreier B, Segal DJ, Barbas CF (2000). "Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains". J. Mol. Biol. 303 (4): 489–502. doi:10.1006/jmbi.2000.4133. PMID 11054286.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Rousseau-Merck MF, Duro D, Berger R, Thiesen HJ (1995). "Chromosomal localization of two KOX zinc finger genes on chromosome bands 7q21-q22". Ann. Genet. 38 (2): 81–4. PMID 7486829.
• Thiesen HJ (1991). "Multiple genes encoding zinc finger domains are expressed in human T cells". New Biol. 2 (4): 363–74. PMID 2288909.