ZNF268

Zinc finger protein 268 is a protein that in humans is encoded by the ZNF268 gene. ZNF268 is associated with cervical cancer.

ZNF268
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2EL4, 2EL5, 2EL6, 2EM1, 2EMV, 2EMW, 2EMX, 2EMY, 2EN0, 2EN6, 2EN7, 2EOF, 2EOG, 2EOI, 2EOJ, 2EOK, 2EOL, 2EOP, 2EPV, 2EPW, 2EPY, 2YTF, 2YTQ
Identifiers
Aliases	ZNF268, HZF3, zinc finger protein 268
External IDs	OMIM: 604753; HomoloGene: 124392; GeneCards: ZNF268; OMA:ZNF268 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q24.33 Start 133,181,409 bp End 133,214,832 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad Epithelium of choroid plexus Achilles tendon ventricular zone ganglionic eminence buccal mucosa cell testicle retinal pigment epithelium islet of Langerhans epithelium of colon n/a More reference expression data BioGPS n/a
Gene ontology Molecular function nucleic acid binding DNA binding DNA-binding transcription factor activity metal ion binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component intracellular anatomical structure cytoplasm actin cytoskeleton nucleus cytosol Biological process regulation of transcription, DNA-templated cell differentiation positive regulation of protein phosphorylation positive regulation of protein catabolic process regulation of protein heterodimerization activity positive regulation of cell migration cellular response to tumor necrosis factor negative regulation of apoptotic process negative regulation of transcription by RNA polymerase II positive regulation of protein homodimerization activity transcription, DNA-templated positive regulation of cell differentiation positive regulation of cell population proliferation regulation of mitotic cell cycle positive regulation of apoptotic process negative regulation of cell population proliferation positive regulation of transcription by RNA polymerase II positive regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10795 n/a Ensembl ENSG00000090612 n/a UniProt Q14587 n/a RefSeq (mRNA) NM_152943 NM_001165881 NM_001165882 NM_001165883 NM_001165884 NM_001165885 NM_001165886 NM_001165887 NM_003415 n/a RefSeq (protein) NP_001159353 NP_001159354 NP_001159355 NP_001159356 NP_001159357 NP_001159358 NP_001159359 NP_003406 NP_694422 n/a Location (UCSC) Chr 12: 133.18 – 133.21 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Further reading

• Shao H, Zhu C, Zhao Z, et al. (2006). "KRAB-containing zinc finger gene ZNF268 encodes multiple alternatively spliced isoforms that contain transcription regulatory domains". Int. J. Mol. Med. 18 (3): 457–63. doi:10.3892/ijmm.18.3.457. PMID 16865230.
• Guo MX, Wang D, Shao HJ, et al. (2006). "Transcription of human zinc finger ZNF268 gene requires an intragenic promoter element". J. Biol. Chem. 281 (34): 24623–36. doi:10.1074/jbc.M602753200. PMID 16787922.
• Sun Y, Shao H, Li Z, et al. (2005). "ZNF268, a novel kruppel-like zinc finger protein, is implicated in early human liver development". Int. J. Mol. Med. 14 (6): 971–5. doi:10.3892/ijmm.14.6.971. PMID 15547661.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Sun Y, Gou DM, Liu H, et al. (2004). "The KRAB domain of zinc finger gene ZNF268: a potential transcriptional repressor". IUBMB Life. 55 (3): 127–31. doi:10.1080/1521654031000110208. PMID 12822888. S2CID 43391168.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gou DM, Sun Y, Gao L, et al. (2001). "Cloning and characterization of a novel Krüppel-like zinc finger gene, ZNF268, expressed in early human embryo". Biochim. Biophys. Acta. 1518 (3): 306–10. doi:10.1016/s0167-4781(01)00194-4. hdl:10397/34032. PMID 11311945.