Zinc finger protein 346 is a protein that in humans is encoded by the ZNF346 gene.[5][6]

ZNF346
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesZNF346, JAZ, Zfp346, zinc finger protein 346
External IDsOMIM: 605308; MGI: 1349417; HomoloGene: 8073; GeneCards: ZNF346; OMA:ZNF346 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012017

RefSeq (protein)

NP_036147
NP_001365863
NP_001365864

Location (UCSC)Chr 5: 177.02 – 177.08 MbChr 13: 55.11 – 55.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113761Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021481Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yang M, May WS, Ito T (Nov 1999). "JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization". J Biol Chem. 274 (39): 27399–406. doi:10.1074/jbc.274.39.27399. PMID 10488071.
  6. ^ a b "Entrez Gene: ZNF346 zinc finger protein 346".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.