ZRF1

DnaJ homolog subfamily C member 2 is a protein that in humans is encoded by the DNAJC2 gene.

DNAJC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M2E
Identifiers
Aliases	DNAJC2, MPHOSPH11, MPP11, ZRF1, ZUO1, DnaJ heat shock protein family (Hsp40) member C2
External IDs	OMIM: 605502; MGI: 99470; HomoloGene: 31656; GeneCards: DNAJC2; OMA:DNAJC2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q22.1 Start 103,312,289 bp End 103,344,830 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 A3|5 9.97 cM Start 21,962,265 bp End 21,990,249 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve tendon of biceps brachii glutes nasal epithelium cartilage tissue hair follicle gonad Achilles tendon sperm monocyte Top expressed in tail of embryo genital tubercle seminiferous tubule epiblast spermatocyte spermatid primitive streak primary oocyte migratory enteric neural crest cell embryo More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding Hsp70 protein binding histone binding chromatin binding ATPase activator activity RNA binding ubiquitin modification-dependent histone binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm cytosol nuclear membrane nucleus nucleoplasm Biological process positive regulation of transcription, DNA-templated regulation of cellular response to heat DNA replication 'de novo' cotranslational protein folding regulation of transcription, DNA-templated negative regulation of DNA biosynthetic process transcription, DNA-templated positive regulation of ATP-dependent activity chromatin organization regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27000 22791 Ensembl ENSG00000105821 ENSMUSG00000029014 UniProt Q99543 P54103 RefSeq (mRNA) NM_001129887 NM_014377 NM_001362667 NM_001362668 NM_009584 RefSeq (protein) NP_001123359 NP_055192 NP_001349596 NP_001349597 NP_033610 Location (UCSC) Chr 7: 103.31 – 103.34 Mb Chr 5: 21.96 – 21.99 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Further reading

• Resto VA, Caballero OL, Buta MR, et al. (2000). "A putative oncogenic role for MPP11 in head and neck squamous cell cancer". Cancer Res. 60 (19): 5529–35. PMID 11034098.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Greiner J, Ringhoffer M, Taniguchi M, et al. (2003). "Characterization of several leukemia-associated antigens inducing humoral immune responses in acute and chronic myeloid leukemia". Int. J. Cancer. 106 (2): 224–31. doi:10.1002/ijc.11200. PMID 12800198. S2CID 24284888.
• Greiner J, Ringhoffer M, Taniguchi M, et al. (2004). "mRNA expression of leukemia-associated antigens in patients with acute myeloid leukemia for the development of specific immunotherapies". Int. J. Cancer. 108 (5): 704–11. doi:10.1002/ijc.11623. PMID 14696097. S2CID 24565397.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Hundley HA, Walter W, Bairstow S, Craig EA (2005). "Human Mpp11 J protein: ribosome-tethered molecular chaperones are ubiquitous". Science. 308 (5724): 1032–4. Bibcode:2005Sci...308.1032H. doi:10.1126/science.1109247. PMID 15802566. S2CID 24164629.
• Otto H, Conz C, Maier P, et al. (2005). "The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complex". Proc. Natl. Acad. Sci. U.S.A. 102 (29): 10064–9. Bibcode:2005PNAS..10210064O. doi:10.1073/pnas.0504400102. PMC 1177401. PMID 16002468.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.