ZWINT

ZW10 interactor (Zwint-1) is a protein that in humans is encoded by the ZWINT gene.

ZWINT
Identifiers
Aliases	ZWINT, HZwint-1, KNTC2AP, ZWINT1, SIP30, ZW10 interacting kinetochore protein
External IDs	OMIM: 609177; MGI: 1289227; HomoloGene: 48496; GeneCards: ZWINT; OMA:ZWINT - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q21.1 Start 56,357,227 bp End 56,361,273 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10 B5.3|10 37.15 cM Start 72,490,677 bp End 72,510,796 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte ventricular zone embryo ganglionic eminence trabecular bone bone marrow gonad rectum gingival epithelium Top expressed in ventromedial nucleus paraventricular nucleus of hypothalamus lateral hypothalamus medial vestibular nucleus entorhinal cortex superior colliculus perirhinal cortex mammillary body inferior colliculi arcuate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein N-terminus binding Cellular component cytoplasm neuron projection dendrite chromosome, centromeric region intracellular membrane-bounded organelle kinetochore chromosome nucleus nucleoplasm cytosol nuclear body Biological process mitotic sister chromatid segregation mitotic cell cycle checkpoint signaling cell division cell cycle establishment of localization in cell Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11130 52696 Ensembl ENSG00000122952 ENSMUSG00000019923 UniProt O95229 Q9CQU5 RefSeq (mRNA) NM_001005413 NM_001005414 NM_007057 NM_032997 NM_001293683 NM_001293684 NM_025635 RefSeq (protein) NP_001005413 NP_008988 NP_127490 NP_001280612 NP_001280613 NP_079911 Location (UCSC) Chr 10: 56.36 – 56.36 Mb Chr 10: 72.49 – 72.51 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

Zwint-1 is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Interactions

ZWINT has been shown to interact with MIS12. ZWINT has also been shown to interact with RAB3C

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Starr DA, Saffery R, Li Z, Simpson AE, Choo KH, Yen TJ, Goldberg ML (Jun 2000). "HZwint-1, a novel human kinetochore component that interacts with HZW10". Journal of Cell Science. 113 ( Pt 11) (11): 1939–50. doi:10.1242/jcs.113.11.1939. PMID 10806105.
• Musio A, Mariani T, Montagna C, Zambroni D, Ascoli C, Ried T, Vezzoni P (Apr 2004). "Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes". Gene. 331: 33–40. doi:10.1016/j.gene.2004.01.028. PMID 15094189.
• Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (Sep 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
• Wang H, Hu X, Ding X, Dou Z, Yang Z, Shaw AW, Teng M, Cleveland DW, Goldberg ML, Niu L, Yao X (Dec 2004). "Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling". The Journal of Biological Chemistry. 279 (52): 54590–8. doi:10.1074/jbc.M407588200. PMID 15485811.
• Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (Nov 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821. S2CID 39408000.
• Le XF, Lammayot A, Gold D, Lu Y, Mao W, Chang T, Patel A, Mills GB, Bast RC (Jan 2005). "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling". The Journal of Biological Chemistry. 280 (3): 2092–104. doi:10.1074/jbc.M403080200. PMID 15504738.
• Kops GJ, Kim Y, Weaver BA, Mao Y, McLeod I, Yates JR, Tagaya M, Cleveland DW (Apr 2005). "ZW10 links mitotic checkpoint signaling to the structural kinetochore". The Journal of Cell Biology. 169 (1): 49–60. doi:10.1083/jcb.200411118. PMC 1351127. PMID 15824131.
• Lin YT, Chen Y, Wu G, Lee WH (Nov 2006). "Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control". Oncogene. 25 (52): 6901–14. doi:10.1038/sj.onc.1209687. PMID 16732327. S2CID 11176319.

External links

• ZWINT human gene location in the UCSC Genome Browser.
• ZWINT human gene details in the UCSC Genome Browser.