Zacherle is a surname. Notable people with the surname include:
- Franz Zacherle, Austrian sculptor, born in Hall in Tirol, died around 1790
- Thomas Zacherle, Austrian abbot of the monastery of Fiecht
- Bonnie Dale Zacherle, American illustrator and designer
- John Zacherle (1918–2016), American television personality
John Zacherle is the uncle of Bonnie Dale Zacherle.