Zaimis (Greek: Ζαΐμης) is a Greek surname and may refer to the following people:
- Alexandros Zaimis (1855-1936), Prime Minister of Greece six times between 1897 and 1928
- Andreas Zaimis (1791–1840), Greek freedom fighter and politician
- Eleanor Zaimis (1915–1982), Greek-British academic
- Georgios Zaimis (1937–2020), Greek sports sailor, Olympic champion in 1960
- Ioannis Zaimis (1797–1882), Greek politician, first Mayor of Patras
- Thrasyvoulos Zaimis (1822–1880), Prime Minister of Greece two times between 1869 and 1872