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Zhu Jieping

Jieping Zhu (祝介平; born 1965 in Xiaoshan, Hangzhou, China) is an organic chemist specializing in natural product total synthesis and organometallics. He is a professor of chemistry at EPFL (École Polytechnique Fédérale de Lausanne) and the head of the Laboratory of Synthesis and Natural Products.[1]

Professor
Jieping Zhu
Jieping Zhu in 2021
Born1965 (age 58–59)
Xiaoshan, Hangzhou, China
CitizenshipFrance
Known forTotal synthesis of complex natural products and bioactive compounds, development of novel multicomponent reactions, domino process and catalytic enantioselective transformation
Awards2016 Natural Product Chemistry Award (RSC)
Prix SCF-DCO
Chang Jiang Scholars
CNRS Silver Medal
Academic background
EducationChemistry
Alma materHangzhou Normal University
Lanzhou University
French National Centre for Scientific Research
ThesisSynthèse asymétrique de dérivés de l'histrionicotoxine et de spiropipéridines apparentées (Asymmetric synthesis of histrionicotoxin derivatives and related spiropiperidines) (1991)
Doctoral advisorJean-Charles Quirion
Henri-Philippe Husson
Other advisorsDerek Barton
Academic work
DisciplineChemistry
Sub-disciplineTotal synthesis
InstitutionsEPFL (École Polytechnique Fédérale de Lausanne)
Main interestsTotal synthesis
Organometallics
Asymmetric synthesis
Websitehttps://www.epfl.ch/labs/lspn/

Career

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Zhu studied chemistry at Hangzhou Normal University and at Lanzhou University, both in China. He then joined Henri-Philippe Husson and Jean-Charles Quirion to pursue a PhD in organic chemistry at the Institute de Chimie des Substances Naturelles at the French National Centre for Scientific Research.[2] In 1991, he graduated with a thesis on Synthèse asymétrique de dérivés de l'histrionicotoxine et de spiropipéridines apparentées (Asymmetric synthesis of histrionicotoxin derivatives and related spiropiperidines).[3]

As a postdoctoral researcher he went to work with Derek Barton at the Texas A&M University and pursue research on phosphonic acid synthesis.[4] In 1992, he joined Institut de Chimie des Substances Naturelles (ICSN) as a chargé de recherche. In 2000, he was promoted to directeur de recherche 2nd class, then 1st class in 2006 in the same institute.

Since 2010, he has been full professor of chemistry at EPFL's School of Basic Sciences of EPFL.

Research

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Zhu’s research focuses on the development of new synthetic methods including multicomponent reactions,[5][6][7] catalytic enantioselective transformations,[8][9][10] and transition metal catalyzed domino processes.[11][12][13] He is also immersed in the total synthesis of complex natural products and bioactive molecules.[14][15][16][17]

Distinctions

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Zhu is the recipient of among others the 2016 Natural Product Chemistry Award from the Royal Society of Chemistry (RSC) Natural Product Chemistry Award,[18] the 2010 Division of Organic Chemistry (Prix SCF-DCO) award from the Société chimique de France (French Chemical Society),[19] the 2009 Chang Jiang Scholars (Qinghua University) awarded by the Chinese Ministry of Education, the 2009 Silver Medal of CNRS,[20] the 2008 Novartis Chemistry Lectureship, the 2004 Liebig Lectureship of the German Chemical Society,[21] and the 2003 Prix “Emile Jungfleisch” of French Academy of Science.[22]

He is a fellow of the Royal Society of Chemistry. He is editor at the journal Tetrahedron Letters.[23]

Selected works

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Books

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  • Zhu, Jieping; Bienaymé, Hugues (6 March 2006). Multicomponent Reactions. ISBN 9783527604241.
  • Zhu, Jieping; Wang, Qian; Wang, Meixiang (15 October 2014). Multicomponent Reactions in Organic Synthesis. ISBN 9783527678204.

Papers

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  • Zhu, Jieping (2003). "Recent Developments in the Isonitrile‐Based Multicomponent Synthesis of Heterocycles". European Journal of Organic Chemistry. 2003 (7): 1133–1144. doi:10.1002/ejoc.200390167.
  • Janvier, Pierre; Sun, Xiaowen; Bienaymé, Hugues; Zhu, Jieping (2002). "Ammonium Chloride-Promoted Four-Component Synthesis of Pyrrolo[3,4-b]pyridin-5-one". Journal of the American Chemical Society. 124 (11): 2560–2567. doi:10.1021/ja017563a. PMID 11890807.
  • Chen, Jinchun; Chen, Xiaochuan; Bois-Choussy, Michèle; Zhu, Jieping (2006). "Total Synthesis of Ecteinascidin 743". Journal of the American Chemical Society. 128 (1): 87–89. doi:10.1021/ja0571794. PMID 16390134.
  • Xu, Zhengren; Wang, Qian; Zhu, Jieping (2015). "Total Syntheses of (−)-Mersicarpine, (−)-Scholarisine G, (+)-Melodinine e, (−)-Leuconoxine, (−)-Leuconolam, (−)-Leuconodine A, (+)-Leuconodine F, and (−)-Leuconodine C: Self-Induced Diastereomeric Anisochronism (SIDA) Phenomenon for Scholarisine G and Leuconodines a and C". Journal of the American Chemical Society. 137 (20): 6712–6724. doi:10.1021/jacs.5b03619. PMID 25946614.
  • Andres, Rémi; Wang, Qian; Zhu, Jieping (2020). "Asymmetric Total Synthesis of (−)-Arborisidine and (−)-19-epi-Arborisidine Enabled by a Catalytic Enantioselective Pictet–Spengler Reaction". Journal of the American Chemical Society. 142 (33): 14276–14285. doi:10.1021/jacs.0c05804. PMID 32692169. S2CID 220672260.
  • Delayre, Bastien; Piemontesi, Cyril; Wang, Qian; Zhu, Jieping (2020). "Ti Cl 3 ‐Mediated Synthesis of 2,3,3‐Trisubstituted Indolenines: Total Synthesis of (+)‐1,2‐Dehydroaspidospermidine, (+)‐Condyfoline, and (−)‐Tubifoline". Angewandte Chemie International Edition. 59 (33): 13990–13997. doi:10.1002/anie.202005380. PMID 32415682. S2CID 218657815.

References

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  1. ^ "LSPN". www.epfl.ch. Retrieved 2021-04-13.
  2. ^ Zhu, Jieping; Quirion, Jean Charles; Husson, Henri Philippe (November 1993). "Asymmetric synthesis. 29. Preparation of 1,8-diazaspiro[5.5]undecane derivatives". The Journal of Organic Chemistry. 58 (23): 6451–6456. doi:10.1021/jo00075a048. ISSN 0022-3263.
  3. ^ Zhu, Jieping; Husson, Henri-Philippe (1991). Synthèse asymétrique de dérivés de l'histrionicotoxine et de spiropipéridines apparentées.
  4. ^ Barton, Derek H. R.; Zhu, Jieping (March 1993). "Elemental white phosphorus as a radical trap: a new and general route to phosphonic acids". Journal of the American Chemical Society. 115 (5): 2071–2072. doi:10.1021/ja00058a082. ISSN 0002-7863.
  5. ^ Bao, Xu; Yokoe, Takayuki; Ha, Tu M.; Wang, Qian; Zhu, Jieping (2018-09-13). "Copper-catalyzed methylative difunctionalization of alkenes". Nature Communications. 9 (1): 3725. Bibcode:2018NatCo...9.3725B. doi:10.1038/s41467-018-06246-6. ISSN 2041-1723. PMC 6137206. PMID 30213939. S2CID 52273111.
  6. ^ Tong, Shuo; Piemontesi, Cyril; Wang, Qian; Wang, Mei-Xiang; Zhu, Jieping (2017). "Silver-Catalyzed Three-Component 1,1-Aminoacylation of Homopropargylamines: α-Additions for Both Terminal Alkynes and Isocyanides". Angewandte Chemie International Edition. 56 (27): 7958–7962. doi:10.1002/anie.201704727. ISSN 1521-3773. PMID 28493495.
  7. ^ Bunescu, Ala; Ha, Tu M.; Wang, Qian; Zhu, Jieping (2017-08-21). "Copper-Catalyzed Three-Component Carboazidation of Alkenes with Acetonitrile and Sodium Azide". Angewandte Chemie. 129 (35): 10691–10694. Bibcode:2017AngCh.12910691B. doi:10.1002/ange.201705353.
  8. ^ Zheng, Sheng-Cai; Wang, Qian; Zhu, Jieping (2019). "Catalytic Atropenantioselective Heteroannulation between Isocyanoacetates and Alkynyl Ketones: Synthesis of Enantioenriched Axially Chiral 3-Arylpyrroles". Angewandte Chemie International Edition. 58 (5): 1494–1498. doi:10.1002/anie.201812654. ISSN 1521-3773. PMID 30480863. S2CID 53755451.
  9. ^ Kong, Wangqing; Wang, Qian; Zhu, Jieping (2015-12-30). "Palladium-Catalyzed Enantioselective Domino Heck/Intermolecular C–H Bond Functionalization: Development and Application to the Synthesis of (+)-Esermethole". Journal of the American Chemical Society. 137 (51): 16028–16031. doi:10.1021/jacs.5b11625. ISSN 0002-7863. PMID 26681502.
  10. ^ Wu, Hua; Wang, Qian; Zhu, Jieping (2019-07-24). "Catalytic Enantioselective Pinacol and Meinwald Rearrangements for the Construction of Quaternary Stereocenters". Journal of the American Chemical Society. 141 (29): 11372–11377. doi:10.1021/jacs.9b04551. ISSN 0002-7863. PMID 31282151. S2CID 195829491.
  11. ^ Budai, Balázs; Leclair, Alexandre; Wang, Qian; Zhu, Jieping (2019-07-22). "Copper‐Catalyzed 1,2‐Methoxy Methoxycarbonylation of Alkenes with Methyl Formate". Angewandte Chemie. 131 (30): 10411–10415. doi:10.1002/ange.201904263. ISSN 0044-8249. S2CID 240966286.
  12. ^ Piou, Tiffany; Bunescu, Ala; Wang, Qian; Neuville, Luc; Zhu, Jieping (2013). "Palladium‐Catalyzed Through‐Space C(sp3)–H and C(sp2)–H Bond Activation by 1,4‐Palladium Migration: Efficient Synthesis of [3,4]‐Fused Oxindoles". Angewandte Chemie International Edition. 52 (47): 12385–12389. doi:10.1002/anie.201306532. ISSN 1521-3773. PMID 24105995.
  13. ^ Bao, Xu; Wang, Qian; Zhu, Jieping (2019-02-11). "Dual Photoredox/Copper Catalysis for the Remote C(sp 3 )−H Functionalization of Alcohols and Alkyl Halides by N -Alkoxypyridinium Salts". Angewandte Chemie International Edition. 58 (7): 2139–2143. doi:10.1002/anie.201813356. PMID 30589177. S2CID 58653181.
  14. ^ Li, Guang; Piemontesi, Cyril; Wang, Qian; Zhu, Jieping (2019-02-25). "Stereoselective Total Synthesis of Eburnane‐Type Alkaloids Enabled by Conformation‐Directed Cyclization and Rearrangement". Angewandte Chemie International Edition. 58 (9): 2870–2874. doi:10.1002/anie.201813920. ISSN 1433-7851. PMID 30600890. S2CID 58582272.
  15. ^ Torres-Ochoa, Rubén O.; Buyck, Thomas; Wang, Qian; Zhu, Jieping (2018-05-14). "Heteroannulation of Arynes with α-Amino Imides: Synthesis of 2,2-Disubstituted Indolin-3-ones and Application to the Enantioselective Total Synthesis of (+)-Hinckdentine A". Angewandte Chemie International Edition. 57 (20): 5679–5683. doi:10.1002/anie.201800746. PMID 29600593.
  16. ^ Piemontesi, Cyril; Wang, Qian; Zhu, Jieping (2016-09-07). "Enantioselective Synthesis of (+)-Peganumine A". Journal of the American Chemical Society. 138 (35): 11148–11151. doi:10.1021/jacs.6b07846. ISSN 0002-7863. PMID 27558528. S2CID 207170533.
  17. ^ "Research". www.epfl.ch. Retrieved 2021-04-14.
  18. ^ "Royal Society of Chemistry Prizes and Awards 2016". Angewandte Chemie International Edition. 55 (35): 10181–10182. 2016. doi:10.1002/anie.201605977. ISSN 1521-3773. PMID 27385199.
  19. ^ "Lauréats - Société Chimique de France". www.societechimiquedefrance.fr. Retrieved 2021-04-14.
  20. ^ "Jieping Zhu | CNRS". www.cnrs.fr. Retrieved 2021-04-14.
  21. ^ "Liebig-Lectureship | Gesellschaft Deutscher Chemiker e.V." www.gdch.de (in German). Retrieved 2021-04-14.
  22. ^ "Jieping Zhu". Angewandte Chemie International Edition. 52 (27): 6812–6813. 2013. doi:10.1002/anie.201210061. ISSN 1521-3773.
  23. ^ "Professor Jieping Zhu". Elsevier. Retrieved 2021-04-14.
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