This article may be too technical for most readers to understand.(October 2017) |
Zinc finger protein 426 is a protein that in humans is encoded by the ZNF426 gene. [5]
ZNF426 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | ZNF426, K-RBP, zinc finger protein 426 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | MGI: 1920248; HomoloGene: 23435; GeneCards: ZNF426; OMA:ZNF426 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
editKaposi's sarcoma-associated herpesvirus (KSHV) can be reactivated from latency by the viral protein RTA. The protein encoded by this gene is a zinc finger transcriptional repressor that interacts with RTA to modulate RTA-mediated reactivation of KSHV. While the encoded protein can repress KSHV reactivation, RTA can induce degradation of this protein through the ubiquitin-proteasome pathway to overcome the repression. Several transcript variants encoding different isoforms have been found for this gene.
References
edit- ^ a b c GRCh38: Ensembl release 89: ENSG00000130818 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059475 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Zinc finger protein 426". Retrieved 2016-01-28.
Further reading
editThis article incorporates text from the United States National Library of Medicine, which is in the public domain.