Zinc finger protein 516

ZNF516
Identifiers
Aliases	ZNF516, HsT287, zinc finger protein 516
External IDs	OMIM: 615114; MGI: 2443957; HomoloGene: 37122; GeneCards: ZNF516; OMA:ZNF516 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	76,495,242 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	83,023,439 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; canal of the cervix; ; left testis; ; body of uterus; ; right testis; ; left ovary; ; right uterine tube; ; testicle; ; ectocervix; ; right ovary;
	Top expressed in
	hand; ; granulocyte; ; ascending aorta; ; aortic valve; ; islet of Langerhans; ; trigeminal ganglion; ; Gonadal ridge; ; genital tubercle; ; mandibular prominence; ; abdominal wall;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; sequence-specific DNA binding; DNA binding; cis-regulatory region sequence-specific DNA binding; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	multicellular organism development; positive regulation of transcription, DNA-templated; response to cold; adipose tissue development; regulation of transcription, DNA-templated; transcription by RNA polymerase II; signal transduction; brown fat cell differentiation; transcription, DNA-templated; regulation of transcription by RNA polymerase II; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	9658
	329003
	ENSG00000101493
	ENSMUSG00000058881
	Q92618
	Q7TSH3
	NM_014643
	NM_001177464; NM_183033
	NP_055458
	NP_001170935; NP_898854
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein 516 is a protein that in humans is encoded by the ZNF516 gene.^[5]

Function

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc-finger protein, and belongs to the Krüppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101493 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058881 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Zinc finger protein 516".

Shaffer JR, Feingold E, Wang X, Lee M, Tcuenco K, Weeks DE, Weyant RJ, Crout R, McNeil DW, Marazita ML (January 2013). "GWAS of dental caries patterns in the permanent dentition". Journal of Dental Research. 92 (1): 38–44. doi:10.1177/0022034512463579. PMC 3521449. PMID 23064961.
Shi Y, Sawada J, Sui G, Affar el B, Whetstine JR, Lan F, Ogawa H, Luke MP, Nakatani Y, Shi Y (April 2003). "Coordinated histone modifications mediated by a CtBP co-repressor complex". Nature. 422 (6933): 735–8. doi:10.1038/nature01550. PMID 12700765. S2CID 2670859.
Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
Lee MG, Wynder C, Cooch N, Shiekhattar R (September 2005). "An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation". Nature. 437 (7057): 432–5. doi:10.1038/nature04021. PMID 16079794. S2CID 4396351.
Yashin AI, Wu D, Arbeev KG, Ukraintseva SV (September 2010). "Joint influence of small-effect genetic variants on human longevity". Aging. 2 (9): 612–20. doi:10.18632/aging.100191. PMC 2984609. PMID 20834067.
O'Brien RP, Phelan PJ, Conroy J, O'Kelly P, Green A, Keogan M, O'Neill D, Jennings S, Traynor C, Casey J, McCormack M, Conroy R, Chubb A, Ennis S, Shields DC, Cavalleri GL, Conlon PJ (2013). "A genome-wide association study of recipient genotype and medium-term kidney allograft function". Clinical Transplantation. 27 (3): 379–87. doi:10.1111/ctr.12093. PMID 23432519. S2CID 13087946.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101493 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058881 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Zinc finger protein 516".

[5]

[1]

[2]

[3]

[4]

Zinc finger protein 516

Function

References

Further reading