40S ribosomal protein S13

40S ribosomal protein S13 is a protein that in humans is encoded by the RPS13 gene.

RPS13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 4KZY, 3J7R, 4D61, 4KZX, 4D5L, 5FLX, 4UJD, 3J7P, 4KZZ, 4UJE, 4UJC
Identifiers
Aliases	RPS13, S13, ribosomal protein S13
External IDs	OMIM: 180476; MGI: 1915302; HomoloGene: 128182; GeneCards: RPS13; OMA:RPS13 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.1 Start 17,074,388 bp End 17,077,715 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 F1 Start 115,930,740 bp End 115,933,430 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte ganglionic eminence lymph node left ovary right ovary canal of the cervix gonad gallbladder uterine tube endometrium Top expressed in epiblast embryo embryo lens ventricular zone spleen ganglionic eminence thymus primary oocyte neural tube More reference expression data BioGPS n/a
Gene ontology Molecular function small ribosomal subunit rRNA binding structural constituent of ribosome protein binding mRNA binding 5.8S rRNA binding RNA binding mRNA 5'-UTR binding Cellular component cytosol ribosome membrane focal adhesion intracellular anatomical structure cytosolic small ribosomal subunit nucleolus extracellular exosome nucleus nucleoplasm extracellular matrix postsynaptic density Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay negative regulation of RNA splicing protein biosynthesis rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6207 68052 Ensembl ENSG00000110700 ENSMUSG00000090862 UniProt P62277 P62301 RefSeq (mRNA) NM_001017 NM_026533 RefSeq (protein) NP_001008 NP_080809 Location (UCSC) Chr 11: 17.07 – 17.08 Mb Chr 7: 115.93 – 115.93 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and fifth introns. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Interactions

RPS13 has been shown to interact with PDCD4.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Suzuki K, Olvera J, Wool IG (1990). "The primary structure of rat ribosomal protein S13". Biochem. Biophys. Res. Commun. 171 (2): 519–24. doi:10.1016/0006-291X(90)91176-S. PMID 2403345.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
• Kenmochi N, Higa S, Yoshihama M, Tanaka T (1996). "U14 snoRNAs are encoded in introns of human ribosomal protein S13 gene". Biochem. Biophys. Res. Commun. 228 (2): 371–4. doi:10.1006/bbrc.1996.1668. PMID 8920921.
• Caldwell GM, Eddy RL, Day CD, et al. (2001). "Mapping of genes and transcribed sequences in a gene rich 400-kb region on human chromosome 11p15.1→p14". Cytogenet. Cell Genet. 92 (1–2): 103–7. doi:10.1159/000056877. PMID 11306805. S2CID 46081338.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Kang MJ, Ahn HS, Lee JY, et al. (2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts". Biochem. Biophys. Res. Commun. 293 (1): 617–21. doi:10.1016/S0006-291X(02)00264-4. PMID 12054647.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lundgren J, Masson P, Realini CA, Young P (2003). "Use of RNA interference and complementation to study the function of the Drosophila and human 26S proteasome subunit S13". Mol. Cell. Biol. 23 (15): 5320–30. doi:10.1128/MCB.23.15.5320-5330.2003. PMC 165711. PMID 12861018.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Shi Y, Zhai H, Wang X, et al. (2004). "Ribosomal proteins S13 and L23 promote multidrug resistance in gastric cancer cells by suppressing drug-induced apoptosis". Exp. Cell Res. 296 (2): 337–46. doi:10.1016/j.yexcr.2004.02.009. PMID 15149863.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Malygin A, Parakhnevitch N, Karpova G (2005). "Human ribosomal protein S13: cloning, expression, refolding, and structural stability". Biochim. Biophys. Acta. 1747 (1): 93–7. doi:10.1016/j.bbapap.2004.10.001. PMID 15680243.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

• Overview of all the structural information available in the PDB for UniProt: P62277 (40S ribosomal protein S13) at the PDBe-KB.