ABI1

Abl interactor 1 also known as Abelson interactor 1 (Abi-1) is a protein that in humans is encoded by the ABI1 gene.

ABI1
Identifiers
Aliases	ABI1, ABI-1, ABLBP4, E3B1, NAP1BP, SSH3BP, SSH3BP1, abl interactor 1
External IDs	OMIM: 603050; MGI: 104913; HomoloGene: 38053; GeneCards: ABI1; OMA:ABI1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10p12.1 Start 26,746,593 bp End 26,861,087 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 A3|2 15.18 cM Start 22,830,085 bp End 22,930,253 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of nasopharynx amniotic fluid palpebral conjunctiva cartilage tissue oral cavity bronchial epithelial cell skin of arm bone marrow thymus mucosa of paranasal sinus Top expressed in mesenteric lymph nodes subiculum granulocyte lateral septal nucleus left lung lobe parotid gland lobe of cerebellum skin of external ear anterior amygdaloid area ventral tegmental area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tyrosine kinase activator activity protein-containing complex binding cytoskeletal protein binding protein binding SH3 domain binding cadherin binding Cellular component cytoplasm cytosol postsynaptic membrane cell projection postsynaptic density SCAR complex membrane filopodium growth cone plasma membrane synapse intracellular anatomical structure cell junction cell leading edge endoplasmic reticulum neuron projection extracellular exosome cytoskeleton nucleus lamellipodium filopodium tip Biological process somitogenesis megakaryocyte development Fc-gamma receptor signaling pathway involved in phagocytosis transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of protein tyrosine kinase activity vascular endothelial growth factor receptor signaling pathway peptidyl-tyrosine phosphorylation viral process lamellipodium morphogenesis negative regulation of cell population proliferation dendrite morphogenesis actin polymerization or depolymerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10006 11308 Ensembl ENSG00000136754 ENSMUSG00000058835 UniProt Q8IZP0 Q8CBW3 RefSeq (mRNA) NM_001012750 NM_001012751 NM_001012752 NM_001178116 NM_001178119 NM_001178120 NM_001178121 NM_001178122 NM_001178123 NM_001178124 NM_001178125 NM_005470 NM_001348029 NM_001348030 NM_001348031 NM_001348032 NM_001348033 NM_001348034 NM_001077190 NM_001077192 NM_001077193 NM_007380 NM_145994 NM_001331043 NM_001331044 NM_001331045 NM_001377510 NM_001377511 NM_001377512 NM_001377513 RefSeq (protein) NP_001012768 NP_001012769 NP_001012770 NP_001171587 NP_001171590 NP_001171591 NP_001171592 NP_001171593 NP_001171594 NP_001171595 NP_001171596 NP_005461 NP_001334958 NP_001334959 NP_001334960 NP_001334961 NP_001334962 NP_001334963 NP_001070658 NP_001070660 NP_001070661 NP_001317972 NP_001317973 NP_001317974 NP_031406 NP_666106 NP_001364439 NP_001364440 NP_001364441 NP_001364442 Location (UCSC) Chr 10: 26.75 – 26.86 Mb Chr 2: 22.83 – 22.93 Mb PubMed search
Wikidata
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Function

Abl interactor 1 has been found to form a complex with EPS8 and SOS1, and is thought to be involved in the transduction of signals from Ras to Rac. In addition, the encoded protein may play a role in the regulation of EGF-induced Erk pathway activation as well as cytoskeletal reorganization and EGFR signaling. Several transcript variants encoding multiple isoforms have been found for this gene.

Abi1 is adaptor protein. It interacts with c-Abl and WAVE2 which is an actin polymerization regulator. It is known that Abi1 enhances the phosphorylation of WAVE2 by c-Abl. The phosphorylation of c-Abl promotes actin polymerization. Furthermore, Abi1 is a component of the WAVE complex. Some research has shown that knockdown of Abi1 by siRNA promoted degradation of WAVE complex proteins.

Interactions

ABI1 has been shown to interact with

ENAH, NCKAP1, EPS8, and SOS1.

Further reading

• Ichigotani Y, Fujii K, Hamaguchi M, Matsuda S (2002). "In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review)". Int. J. Mol. Med. 9 (6): 591–5. doi:10.3892/ijmm.9.6.591. PMID 12011975.
• Di Fiore PP, Scita G (2002). "Eps8 in the midst of GTPases". Int. J. Biochem. Cell Biol. 34 (10): 1178–83. doi:10.1016/S1357-2725(02)00064-X. PMID 12127568.
• Cardwell C (1977). "Student or worker? International Meeting of Student Nurses (European Group)". Nursing Mirror and Midwives Journal. 143 (19): 38. PMID 1049958.
• Biesova Z, Piccoli C, Wong WT (1997). "Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth". Oncogene. 14 (2): 233–41. doi:10.1038/sj.onc.1200822. PMID 9010225.
• Taki T, Shibuya N, Taniwaki M, et al. (1998). "ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23)". Blood. 92 (4): 1125–30. doi:10.1182/blood.V92.4.1125. PMID 9694699.
• Scita G, Nordstrom J, Carbone R, et al. (1999). "EPS8 and E3B1 transduce signals from Ras to Rac". Nature. 401 (6750): 290–3. Bibcode:1999Natur.401..290S. doi:10.1038/45822. PMID 10499589. S2CID 205045006.
• Courtney KD, Grove M, Vandongen H, et al. (2000). "Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system". Mol. Cell. Neurosci. 16 (3): 244–57. doi:10.1006/mcne.2000.0865. PMID 10995551. S2CID 7370589.
• Fan PD, Goff SP (2000). "Abl Interactor 1 Binds to Sos and Inhibits Epidermal Growth Factor- and v-Abl-Induced Activation of Extracellular Signal-Regulated Kinases". Mol. Cell. Biol. 20 (20): 7591–601. doi:10.1128/MCB.20.20.7591-7601.2000. PMC 86315. PMID 11003655.
• Xu J, Ziemnicka D, Merz GS, Kotula L (2001). "Human spectrin Src homology 3 domain binding protein 1 regulates macropinocytosis in NIH 3T3 cells". J. Cell Sci. 113 (21): 3805–14. doi:10.1242/jcs.113.21.3805. PMC 4511602. PMID 11034908.
• Lanzetti L, Rybin V, Malabarba MG, et al. (2000). "The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5". Nature. 408 (6810): 374–7. Bibcode:2000Natur.408..374L. doi:10.1038/35042605. PMID 11099046. S2CID 4405293.
• Yamamoto A, Suzuki T, Sakaki Y (2001). "Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease". Gene. 271 (2): 159–69. doi:10.1016/S0378-1119(01)00521-2. PMID 11418237.
• Cowan CA, Henkemeyer M (2001). "The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals". Nature. 413 (6852): 174–9. Bibcode:2001Natur.413..174C. doi:10.1038/35093123. PMID 11557983. S2CID 4313061.
• Ichigotani Y, Yokozaki S, Fukuda Y, et al. (2002). "Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells". Cancer Res. 62 (8): 2215–9. PMID 11956071.
• Mammalian Gene Collection Program Team, Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Salomon AR, Ficarro SB, Brill LM, et al. (2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 443–8. Bibcode:2003PNAS..100..443S. doi:10.1073/pnas.2436191100. PMC 141014. PMID 12522270.
• Morerio C, Rosanda C, Rapella A, et al. (2003). "Is t(10;11)(p11.2;q23) involving MLL and ABI-1 genes associated with congenital acute monocytic leukemia?". Cancer Genet. Cytogenet. 139 (1): 57–9. doi:10.1016/S0165-4608(02)00616-7. PMID 12547160.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.

External links

• ABI1 human gene location in the UCSC Genome Browser.
• ABI1 human gene details in the UCSC Genome Browser.