Nck-associated protein 1 is a protein that in humans is encoded by the NCKAP1 gene.[5][6][7][8]

NCKAP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNCKAP1, HEM2, NAP1, NAP125, p125Nap1, NCK associated protein 1
External IDsOMIM: 604891; MGI: 1355333; HomoloGene: 8384; GeneCards: NCKAP1; OMA:NCKAP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013436
NM_205842

NM_001290745
NM_016965
NM_001355410
NM_001355411

RefSeq (protein)

NP_038464
NP_995314

NP_001277674
NP_058661
NP_001342339
NP_001342340

Location (UCSC)Chr 2: 182.91 – 183.04 MbChr 2: 80.33 – 80.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

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NCKAP1 has been shown to interact with RAC1[9] and ABI1.[10]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000061676Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027002Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Suzuki T, Nishiyama K, Yamamoto A, Inazawa J, Iwaki T, Yamada T, Kanazawa I, Sakaki Y (Jan 2000). "Molecular cloning of a novel apoptosis-related gene, human Nap1 (NCKAP1), and its possible relation to Alzheimer disease". Genomics. 63 (2): 246–54. doi:10.1006/geno.1999.6053. PMID 10673335.
  6. ^ Eden S, Rohatgi R, Podtelejnikov AV, Mann M, Kirschner MW (Aug 2002). "Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck". Nature. 418 (6899): 790–3. Bibcode:2002Natur.418..790E. doi:10.1038/nature00859. PMID 12181570. S2CID 4350733.
  7. ^ Matuoka K, Miki H, Takahashi K, Takenawa T (Oct 1997). "A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs". Biochemical and Biophysical Research Communications. 239 (2): 488–92. doi:10.1006/bbrc.1997.7492. PMID 9344857.
  8. ^ "Entrez Gene: NCKAP1 NCK-associated protein 1".
  9. ^ Kitamura Y, Kitamura T, Sakaue H, Maeda T, Ueno H, Nishio S, Ohno S, Osada SI, Sakaue M, Ogawa W, Kasuga M (Mar 1997). "Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac". The Biochemical Journal. 322 (Pt 3): 873–8. doi:10.1042/bj3220873. PMC 1218269. PMID 9148763.
  10. ^ Yamamoto A, Suzuki T, Sakaki Y (Jun 2001). "Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease". Gene. 271 (2): 159–69. doi:10.1016/S0378-1119(01)00521-2. PMID 11418237.

Further reading

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