Ankyrin repeat and BTB/POZ domain-containing protein 1 is a protein that in humans is encoded by the ABTB1 gene.[5][6][7]

ABTB1
Identifiers
AliasesABTB1, BPOZ, BTB3, BTBD21, EF1ABP, PP2259, ankyrin repeat and BTB domain containing 1
External IDsOMIM: 608308; MGI: 1933148; HomoloGene: 32731; GeneCards: ABTB1; OMA:ABTB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032548
NM_172027
NM_172028

NM_030251
NM_001362152

RefSeq (protein)

NP_115937
NP_742024

NP_084527
NP_001349081

Location (UCSC)Chr 3: 127.67 – 127.68 MbChr 6: 88.81 – 88.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes a protein with an ankyrin repeat region and two BTB/POZ domains, which are thought to be involved in protein-protein interactions. Expression of this gene is activated by the phosphatase and tensin homolog, a tumor suppressor. Alternate splicing results in three transcript variants encoding different isoforms.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114626Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030083Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dai KS, Wei W, Liew CC (Sep 2000). "Molecular cloning and characterization of a novel human gene containing ankyrin repeat and double BTB/POZ domain". Biochem Biophys Res Commun. 273 (3): 991–6. doi:10.1006/bbrc.2000.3053. PMID 10891360.
  6. ^ Unoki M, Nakamura Y (Aug 2001). "Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway". Oncogene. 20 (33): 4457–65. doi:10.1038/sj.onc.1204608. PMID 11494141.
  7. ^ a b "Entrez Gene: ABTB1 ankyrin repeat and BTB (POZ) domain containing 1".
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Further reading

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