Alkaline phosphatase, intestinal also known as ALPI is a type of alkaline phosphatase that in humans is encoded by the ALPI gene.[5][6]

ALPI
Identifiers
AliasesALPI, IAP, alkaline phosphatase, intestinal
External IDsOMIM: 171740; MGI: 87984; HomoloGene: 134333; GeneCards: ALPI; OMA:ALPI - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001631

NM_007432

RefSeq (protein)

NP_001622

n/a

Location (UCSC)Chr 2: 232.46 – 232.46 MbChr 1: 87.05 – 87.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Intestinal alkaline phosphatase is an endogenous protein that plays an essential function in the maintenance of gut homeostasis. The protein is responsible for detoxifying bacterial toxins, dephosphorylating phosphorylated nucleotides, regulating lipid absorption in the intestine, and regulating the microbiome in the intestine.[7] In addition to these functions, intestinal alkaline phosphatase can also modulate bicarbonate secretion and can modulate the pH of the duodenum.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163295Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036500Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Berger J, Garattini E, Hua JC, Udenfriend S (February 1987). "Cloning and sequencing of human intestinal alkaline phosphatase cDNA". Proceedings of the National Academy of Sciences of the United States of America. 84 (3): 695–698. Bibcode:1987PNAS...84..695B. doi:10.1073/pnas.84.3.695. PMC 304282. PMID 3468508.
  6. ^ Henthorn PS, Raducha M, Edwards YH, Weiss MJ, Slaughter C, Lafferty MA, Harris H (March 1987). "Nucleotide and amino acid sequences of human intestinal alkaline phosphatase: close homology to placental alkaline phosphatase". Proceedings of the National Academy of Sciences of the United States of America. 84 (5): 1234–1238. Bibcode:1987PNAS...84.1234H. doi:10.1073/pnas.84.5.1234. PMC 304401. PMID 3469665.
  7. ^ Fawley J, Gourlay DM (May 2016). "Intestinal alkaline phosphatase: a summary of its role in clinical disease". The Journal of Surgical Research. 202 (1): 225–234. doi:10.1016/j.jss.2015.12.008. PMC 4834149. PMID 27083970.
  8. ^ Lallès JP (June 2010). "Intestinal alkaline phosphatase: multiple biological roles in maintenance of intestinal homeostasis and modulation by diet". Nutrition Reviews. 68 (6): 323–332. doi:10.1111/j.1753-4887.2010.00292.x. PMID 20536777.
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Further reading

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