ARPC4

Actin-related protein 2/3 complex subunit 4 is a protein that in humans is encoded by the ARPC4 gene.

ARPC4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2P9N, 1TYQ, 1U2V, 4JD2, 3DXK, 3UKU, 3UKR, 2P9P, 2P9K, 2P9U, 3ULE, 3RSE, 2P9S, 2P9I, 4XF2, 2P9L, 1K8K, 3DXM, 4XEI
Identifiers
Aliases	ARPC4, ARC20, P20-ARC, actin related protein 2/3 complex subunit 4
External IDs	OMIM: 604226; MGI: 1915339; HomoloGene: 4177; GeneCards: ARPC4; OMA:ARPC4 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p25.3 Start 9,792,495 bp End 9,807,101 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 E3 Start 113,355,076 bp End 113,367,409 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte rectum smooth muscle tissue mucosa of transverse colon right coronary artery Descending thoracic aorta gallbladder tibial arteries islet of Langerhans Top expressed in granulocyte blastocyst lip primary visual cortex dentate gyrus of hippocampal formation granule cell superior frontal gyrus thymus mesenteric lymph nodes stroma of bone marrow right kidney More reference expression data BioGPS n/a
Gene ontology Molecular function enzyme binding protein-macromolecule adaptor activity actin filament binding actin binding structural constituent of cytoskeleton protein binding Cellular component cytoplasm cytosol arp2/3 protein complex cell projection extracellular exosome cytoskeleton actin cytoskeleton nucleus site of double-strand break Biological process ephrin receptor signaling pathway actin filament polymerization actin nucleation Fc-gamma receptor signaling pathway involved in phagocytosis Arp2/3 complex-mediated actin nucleation membrane organization regulation of actin filament polymerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10093 68089 Ensembl ENSG00000241553 ENSMUSG00000079426 UniProt P59998 P59999 RefSeq (mRNA) NM_005718 NM_001024959 NM_001024960 NM_001198780 NM_001170485 NM_001170486 NM_026552 RefSeq (protein) NP_001020130 NP_001020131 NP_001185709 NP_005709 NP_001163956 NP_001163957 NP_080828 Location (UCSC) Chr 3: 9.79 – 9.81 Mb Chr 6: 113.36 – 113.37 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p20 subunit, has yet to be determined. Three transcript variants encoding two distinct isoforms have been found for this gene.

Interactions

ARPC4 has been shown to interact with ARPC5.

Further reading

• Welch MD, Iwamatsu A, Mitchison TJ (1997). "Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes". Nature. 385 (6613): 265–9. Bibcode:1997Natur.385..265W. doi:10.1038/385265a0. PMID 9000076. S2CID 4358529.
• Robinson RC, Turbedsky K, Kaiser DA, Marchand JB, Higgs HN, Choe S, Pollard TD (2001). "Crystal structure of Arp2/3 complex". Science. 294 (5547): 1679–84. Bibcode:2001Sci...294.1679R. doi:10.1126/science.1066333. PMID 11721045. S2CID 18088124.
• Gournier H, Goley ED, Niederstrasser H, Trinh T, Welch MD (2001). "Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity". Mol. Cell. 8 (5): 1041–52. doi:10.1016/S1097-2765(01)00393-8. PMID 11741539.
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Rosentreter A, Hofmann A, Xavier CP, Stumpf M, Noegel AA, Clemen CS (2007). "Coronin 3 involvement in F-actin-dependent processes at the cell cortex". Exp. Cell Res. 313 (5): 878–95. doi:10.1016/j.yexcr.2006.12.015. hdl:10072/14982. PMID 17274980.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• ARPC4 human gene details in the UCSC Genome Browser.