Asif Khan may refer to:
- Asif Khan (actor) (born 1943), Pakistani actor
- Asif Khan (Hong Kong cricketer) (born 1989), Hong Kong cricketer
- Asif Khan (Indian cricketer) (born 1992), Indian cricketer
- Asif Khan (Emirati cricketer) (born 1990), Pakistani cricketer
- Asif Khan (politician), Pakistani politician
- Asif Hossain Khan, Bangladeshi sport shooter
- Asif Muhammad Khan, Indian politician