BBX (gene)

HMG box transcription factor BBX also known as bobby sox homolog or HMG box-containing protein 2 is a protein that in humans is encoded by the BBX gene.

BBX
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WZ6
Identifiers
Aliases	BBX, ARTC1, HBP2, HSPC339, MDS001, bobby sox homolog (Drosophila), HMG-box containing
External IDs	MGI: 1917758; HomoloGene: 10634; GeneCards: BBX; OMA:BBX - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q13.12 Start 107,522,936 bp End 107,811,324 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 B5 Start 50,012,207 bp End 50,252,753 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis tail of epididymis caput epididymis corpus callosum lactiferous duct inferior ganglion of vagus nerve seminal vesicula Achilles tendon saphenous vein testicle Top expressed in cumulus cell spermatid ascending aorta pineal gland Pituitary Gland seminiferous tubule aortic valve lumbar spinal ganglion stroma of bone marrow tail of embryo More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm cytosol Biological process bone development regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56987 70508 Ensembl ENSG00000114439 ENSMUSG00000022641 UniProt Q8WY36 Q8VBW5 RefSeq (mRNA) NM_001142568 NM_001276286 NM_020235 NM_027444 NM_001347240 RefSeq (protein) NP_001136040 NP_001263215 NP_064620 NP_001334169 NP_081720 Location (UCSC) Chr 3: 107.52 – 107.81 Mb Chr 16: 50.01 – 50.25 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

External links

• Human BBX genome location and BBX gene details page in the UCSC Genome Browser.

Further reading

• Caporaso N, Gu F, Chatterjee N, Sheng-Chih J, Yu K, Yeager M, Chen C, Jacobs K, Wheeler W, Landi MT, Ziegler RG, Hunter DJ, Chanock S, Hankinson S, Kraft P, Bergen AW (2009). "Genome-wide and candidate gene association study of cigarette smoking behaviors". PLOS ONE. 4 (2): e4653. Bibcode:2009PLoSO...4.4653C. doi:10.1371/journal.pone.0004653. PMC 2644817. PMID 19247474.
• Wang HY, Peng G, Guo Z, Shevach EM, Wang RF (Mar 2005). "Recognition of a new ARTC1 peptide ligand uniquely expressed in tumor cells by antigen-specific CD4+ regulatory T cells". Journal of Immunology. 174 (5): 2661–70. doi:10.4049/jimmunol.174.5.2661. PMID 15728473.
• Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C (Aug 2009). "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling". Gut. 58 (8): 1078–83. doi:10.1136/gut.2008.169052. PMID 19240061. S2CID 17111427.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Sánchez-Díaz A, Blanco MA, Jones N, Moreno S (Sep 2001). "HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex". Current Genetics. 40 (2): 110–8. doi:10.1007/s002940100241. PMID 11680820. S2CID 30444254.