CCNL1

Cyclin-L1 is a protein that in humans is encoded by the CCNL1 gene.

CCNL1
Identifiers
Aliases	CCNL1, ANIA6A, PRO1073, ania-6a, BM-001, cyclin L1
External IDs	OMIM: 613384; MGI: 1922664; HomoloGene: 10541; GeneCards: CCNL1; OMA:CCNL1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q25.31 Start 157,146,508 bp End 157,160,760 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 E1 Start 65,853,572 bp End 65,865,670 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa granulocyte left uterine tube monocyte left ovary right ovary right lung skin of abdomen left lobe of thyroid gland anterior pituitary Top expressed in granulocyte saccule Rostral migratory stream tail of embryo crypt of lieberkuhn of small intestine pineal gland otic vesicle thymus otic placode genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cyclin-dependent protein serine/threonine kinase regulator activity protein binding Cellular component nuclear speck cyclin-dependent protein kinase holoenzyme complex nucleoplasm nucleus Biological process positive regulation of phosphorylation of RNA polymerase II C-terminal domain RNA processing regulation of cyclin-dependent protein serine/threonine kinase activity regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of cyclin-dependent protein serine/threonine kinase activity regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57018 56706 Ensembl ENSG00000163660 ENSMUSG00000027829 UniProt Q9UK58 Q52KE7 RefSeq (mRNA) NM_001308185 NM_020307 NM_001025442 NM_001025443 NM_019937 NM_001355432 NM_001355433 RefSeq (protein) NP_001295114 NP_064703 NP_064321 NP_001342361 NP_001342362 Location (UCSC) Chr 3: 157.15 – 157.16 Mb Chr 3: 65.85 – 65.87 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

External links

• Human CCNL1 genome location and CCNL1 gene details page in the UCSC Genome Browser.

Further reading

• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Berke JD, Sgambato V, Zhu PP, et al. (2001). "Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin". Neuron. 32 (2): 277–87. doi:10.1016/S0896-6273(01)00465-2. PMID 11683997. S2CID 14486999.
• Redon R, Hussenet T, Bour G, et al. (2002). "Amplicon mapping and transcriptional analysis pinpoint cyclin L as a candidate oncogene in head and neck cancer". Cancer Res. 62 (21): 6211–7. PMID 12414649.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• de Graaf K, Hekerman P, Spelten O, et al. (2004). "Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors". J. Biol. Chem. 279 (6): 4612–24. doi:10.1074/jbc.M310794200. PMID 14623875.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Sticht C, Hofele C, Flechtenmacher C, et al. (2005). "Amplification of Cyclin L1 is associated with lymph node metastases in head and neck squamous cell carcinoma (HNSCC)". Br. J. Cancer. 92 (4): 770–4. doi:10.1038/sj.bjc.6602400. PMC 2361871. PMID 15700036.
• Muller D, Millon R, Théobald S, et al. (2006). "Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma". Br. J. Cancer. 94 (7): 1041–4. doi:10.1038/sj.bjc.6603036. PMC 2361229. PMID 16598186.