CEP70

Centrosomal protein of 70 kDa is a protein that in humans is encoded by the CEP70 gene. The protein interacts with γ-tubulin through its coiled coil domains to localize at the centrosome. CEP70 is involved in organizing microtubules in interphase cells and is required for proper organization and orientation of the mitotic spindle.

CEP70
Identifiers
Aliases	CEP70, BITE, centrosomal protein 70
External IDs	OMIM: 614310; MGI: 1915371; HomoloGene: 11387; GeneCards: CEP70; OMA:CEP70 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q22.3 Start 138,494,344 bp End 138,594,538 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 E3.3 Start 99,243,367 bp End 99,300,404 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon sperm right uterine tube ventricular zone left testis right testis ganglionic eminence body of pancreas duodenum jejunal mucosa Top expressed in zygote secondary oocyte spermatocyte genital tubercle primary oocyte trigeminal ganglion substantia nigra saccule ventricular zone ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding gamma-tubulin binding Cellular component microtubule organizing center cytoskeleton cytoplasm nucleoplasm cytosol nuclear membrane centrosome Biological process G2/M transition of mitotic cell cycle ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle cilium assembly regulation of microtubule cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80321 68121 Ensembl ENSG00000114107 ENSMUSG00000056267 UniProt Q8NHQ1 Q6IQY5 RefSeq (mRNA) NM_001288964 NM_001288965 NM_001288966 NM_001288967 NM_024491 NM_001320598 NM_001320599 NM_001320600 NM_023873 RefSeq (protein) NP_001275893 NP_001275894 NP_001275895 NP_001275896 NP_001307527 NP_001307528 NP_001307529 NP_077817 NP_076362 Location (UCSC) Chr 3: 138.49 – 138.59 Mb Chr 9: 99.24 – 99.3 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

External links

• Human CEP70 genome location and CEP70 gene details page in the UCSC Genome Browser.

Further reading

• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.