Neural cell adhesion molecule L1-like protein also known as close homolog of L1 (CHL1) is a protein that in humans is encoded by the CHL1 gene .[ 6]
This article is about the cell adhesion molecule. For NRT 1.1, a dual-affinity plant nitrate transporter formally known as CHL1
[ 5] , see
major facilitator superfamily .
CHL1 is a cell adhesion molecule closely related to the L1 . In melanocytic cells CHL1 gene expression may be regulated by MITF ,[ 7] and can act as a helicase protein during the interphase stage of mitosis .
The protein, however, has dynamic localisation, meaning that it has not only multiple roles in the cell, but also various locations.
^ a b c GRCh38: Ensembl release 89: ENSG00000134121 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030077 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Pandey, G.; Kanwar, P.; Pandey, A. (2014). Global Comparative Analysis of CBL-CIPK Gene Families in Plants . Springer International Publishing. p. 52. ISBN 978-3-319-09078-8 .
^ Wei MH, Karavanova I, Ivanov SV, Popescu NC, Keck CL, Pack S, Eisen JA, Lerman MI (September 1998). "In silico-initiated cloning and molecular characterization of a novel human member of the L1 gene family of neural cell adhesion molecules". Hum. Genet . 103 (3): 355–64. doi :10.1007/s004390050829 . PMID 9799093 . S2CID 3177127 .
^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy" . Pigment Cell Melanoma Res . 21 (6): 665–76. doi :10.1111/j.1755-148X.2008.00505.x . PMID 19067971 . S2CID 24698373 .
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