CLASP2

Cytoplasmic linker associated protein 2, also known as CLASP2, is a protein which in humans is encoded by the CLASP2 gene.

CLASP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3WOY
Identifiers
Aliases	CLASP2, cytoplasmic linker associated protein 2
External IDs	OMIM: 605853; MGI: 1923749; HomoloGene: 24944; GeneCards: CLASP2; OMA:CLASP2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p22.3 Start 33,496,245 bp End 33,718,356 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 F3 Start 113,741,473 bp End 113,919,682 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum paraflocculus of cerebellum middle frontal gyrus Brodmann area 10 frontal pole endothelial cell lateral nuclear group of thalamus ganglionic eminence subthalamic nucleus inferior ganglion of vagus nerve Top expressed in lateral geniculate nucleus inferior colliculi medial geniculate nucleus pineal gland mammillary body superior colliculus medial dorsal nucleus cerebellar vermis lobe of cerebellum globus pallidus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tyrosine kinase binding dystroglycan binding microtubule binding microtubule plus-end binding actin filament binding protein binding kinetochore binding Cellular component cytoplasm Golgi apparatus cell projection kinetochore microtubule membrane focal adhesion plasma membrane axonal growth cone spindle microtubule organizing center chromosome ruffle membrane trans-Golgi network cell cortex cell leading edge cortical microtubule plus-end cytoplasmic microtubule mitotic spindle basal cortex microtubule chromosome, centromeric region cytoskeleton kinetochore cytosol Biological process vesicle targeting regulation of actin cytoskeleton organization regulation of axon extension Golgi organization mitotic spindle organization regulation of epithelial to mesenchymal transition positive regulation of epithelial cell migration exit from mitosis cell division establishment or maintenance of cell polarity positive regulation of extracellular matrix disassembly positive regulation of basement membrane assembly involved in embryonic body morphogenesis negative regulation of microtubule depolymerization microtubule anchoring regulation of microtubule-based process regulation of microtubule polymerization regulation of microtubule polymerization or depolymerization negative regulation of wound healing, spreading of epidermal cells cell cycle positive regulation of exocytosis negative regulation of stress fiber assembly microtubule organizing center organization negative regulation of focal adhesion assembly regulation of gastrulation microtubule cytoskeleton organization microtubule nucleation platelet-derived growth factor receptor-beta signaling pathway sister chromatid cohesion protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23122 76499 Ensembl ENSG00000163539 ENSMUSG00000033392 UniProt O75122 Q8BRT1 RefSeq (mRNA) NM_001207044 NM_015097 NM_001365627 NM_001365628 NM_001365629 NM_001365630 NM_001365631 NM_001365632 NM_001365633 NM_001365634 NM_001375694 NM_001375697 NM_001375700 NM_001375701 NM_001375703 NM_001375705 NM_001375713 NM_001375715 NM_001375716 NM_001375718 NM_001375720 NM_001081960 NM_001114347 NM_001286599 NM_001286600 NM_001286601 NM_001286602 NM_001286603 NM_029633 RefSeq (protein) NP_001193973 NP_055912 NP_001352556 NP_001352557 NP_001352558 NP_001352559 NP_001352560 NP_001352561 NP_001352562 NP_001352563 NP_001362623 NP_001362626 NP_001362629 NP_001362630 NP_001362632 NP_001362634 NP_001362642 NP_001362644 NP_001362645 NP_001362647 NP_001362649 NP_001075429 NP_001107819 NP_001273528 NP_001273529 NP_001273530 NP_001273531 NP_001273532 NP_083909 Location (UCSC) Chr 3: 33.5 – 33.72 Mb Chr 9: 113.74 – 113.92 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

External links

• Human CLASP2 genome location and CLASP2 gene details page in the UCSC Genome Browser.

Further reading

• Galjart N (2005). "CLIPs and CLASPs and cellular dynamics". Nat. Rev. Mol. Cell Biol. 6 (6): 487–98. doi:10.1038/nrm1664. PMID 15928712. S2CID 23216754.
• Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
• Lemos CL, Sampaio P, Maiato H, et al. (2000). "Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization". EMBO J. 19 (14): 3668–82. doi:10.1093/emboj/19.14.3668. PMC 313969. PMID 10899121.
• Akhmanova A, Hoogenraad CC, Drabek K, et al. (2001). "Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts". Cell. 104 (6): 923–35. doi:10.1016/S0092-8674(01)00288-4. PMID 11290329. S2CID 14443149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Maiato H, Fairley EA, Rieder CL, et al. (2003). "Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics". Cell. 113 (7): 891–904. doi:10.1016/S0092-8674(03)00465-3. hdl:10216/53832. PMID 12837247. S2CID 13936836.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lee H, Engel U, Rusch J, et al. (2004). "The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance". Neuron. 42 (6): 913–26. doi:10.1016/j.neuron.2004.05.020. PMID 15207236.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mimori-Kiyosue Y, Grigoriev I, Lansbergen G, et al. (2005). "CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex". J. Cell Biol. 168 (1): 141–53. doi:10.1083/jcb.200405094. PMC 2171674. PMID 15631994.
• Wittmann T, Waterman-Storer CM (2005). "Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells". J. Cell Biol. 169 (6): 929–39. doi:10.1083/jcb.200412114. PMC 2171640. PMID 15955847.
• Lansbergen G, Grigoriev I, Mimori-Kiyosue Y, et al. (2006). "CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta". Dev. Cell. 11 (1): 21–32. doi:10.1016/j.devcel.2006.05.012. PMID 16824950.
• Mimori-Kiyosue Y, Grigoriev I, Sasaki H, et al. (2006). "Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment". Genes Cells. 11 (8): 845–57. doi:10.1111/j.1365-2443.2006.00990.x. PMID 16866869. S2CID 33744175.
• Pereira AL, Pereira AJ, Maia AR, et al. (2007). "Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function" (PDF). Mol. Biol. Cell. 17 (10): 4526–42. doi:10.1091/mbc.E06-07-0579. PMC 1635371. PMID 16914514.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.